Cognitive and brain function in schizotypal personality disorder

Larry J. Siever, Harold W. Koenigsberg, Philip D Harvey, Vivian Mitropoulou, Marc Laruelle, Anissa Abi-Dargham, Marianne Goodman, Monte Buchsbaum

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been considered: (1) the two may be distinct disorders, (2) they may be essentially identical disorders but expressed with different degrees of severity, or (3) they may be related disorders with a partially overlapping etiology that might account for the many similarities yet the lack of psychosis or severe deficits in schizotypal individuals. Some of the recent research in the structural and functional neuroanatomy, neurochemistry, cognitive function, and pharmacology of schizotypal personality disorder is reviewed with citation of the most recent findings from our laboratory and others. Both schizotypal and schizophrenic subjects appear to show abnormalities in temporal lobe volume, but schizotypal subjects do not appear to show the volumetric decreases in frontal cortex that schizophrenic patients evidence. Abnormalities in thalamic nuclei parallel these findings - the pulvinar, which projects to temporal association and sensory cortices, is reduced in both disorders, but the mediodorsal nucleus, which projects extensively to the frontal cortex, is reduced in schizophrenic patients but not in schizotypal patients. Functional imaging studies suggest that there may be abnormalities in frontal activation in both disorders, but that schizotypal individuals can recruit alternative regions to accomplish tasks requiring frontal lobe activation that may help compensate. Imaging studies of the subcortex including FDG/PET imaging of metabolic activity during a verbal learning task, SPECT imaging studies which measure binding of IBZM and its displacement following amphetamine administration, and plasma HVA determinations following 2-deoxyglucose administration all suggest the possibility of relatively reduced dopaminergic subcortical activity in schizotypal individuals compared to schizophrenic patients. Cognitive function is also impaired in the areas of working memory, verbal learning, and attention in schizotypal patients, as in schizophrenic patients, and they may be particularly susceptible to cognitive tasks with high context dependence, as in schizophrenia. Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions.

Original languageEnglish
Pages (from-to)157-167
Number of pages11
JournalSchizophrenia Research
Volume54
Issue number1-2
DOIs
StatePublished - Mar 1 2002
Externally publishedYes

Fingerprint

Schizotypal Personality Disorder
Cognition
Brain
Frontal Lobe
Verbal Learning
Schizophrenia
Pulvinar
Mediodorsal Thalamic Nucleus
Neurochemistry
Neuroanatomy
Thalamic Nuclei
Deoxyglucose
Amphetamine
Temporal Lobe
Single-Photon Emission-Computed Tomography
Short-Term Memory
Psychotic Disorders
Pharmacology
Research

Keywords

  • Cognitive function
  • Schizophrenia
  • Schizotypal personality disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Siever, L. J., Koenigsberg, H. W., Harvey, P. D., Mitropoulou, V., Laruelle, M., Abi-Dargham, A., ... Buchsbaum, M. (2002). Cognitive and brain function in schizotypal personality disorder. Schizophrenia Research, 54(1-2), 157-167. https://doi.org/10.1016/S0920-9964(01)00363-2

Cognitive and brain function in schizotypal personality disorder. / Siever, Larry J.; Koenigsberg, Harold W.; Harvey, Philip D; Mitropoulou, Vivian; Laruelle, Marc; Abi-Dargham, Anissa; Goodman, Marianne; Buchsbaum, Monte.

In: Schizophrenia Research, Vol. 54, No. 1-2, 01.03.2002, p. 157-167.

Research output: Contribution to journalArticle

Siever, LJ, Koenigsberg, HW, Harvey, PD, Mitropoulou, V, Laruelle, M, Abi-Dargham, A, Goodman, M & Buchsbaum, M 2002, 'Cognitive and brain function in schizotypal personality disorder', Schizophrenia Research, vol. 54, no. 1-2, pp. 157-167. https://doi.org/10.1016/S0920-9964(01)00363-2
Siever LJ, Koenigsberg HW, Harvey PD, Mitropoulou V, Laruelle M, Abi-Dargham A et al. Cognitive and brain function in schizotypal personality disorder. Schizophrenia Research. 2002 Mar 1;54(1-2):157-167. https://doi.org/10.1016/S0920-9964(01)00363-2
Siever, Larry J. ; Koenigsberg, Harold W. ; Harvey, Philip D ; Mitropoulou, Vivian ; Laruelle, Marc ; Abi-Dargham, Anissa ; Goodman, Marianne ; Buchsbaum, Monte. / Cognitive and brain function in schizotypal personality disorder. In: Schizophrenia Research. 2002 ; Vol. 54, No. 1-2. pp. 157-167.
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