Cognition in Early Human Immunodeficiency Virus Infection

Carl Eisdorfer, Robert Morgan, David A. Loewenstein, Jose Szapocznik, Frances L. Wilkie

Research output: Contribution to journalArticlepeer-review

173 Scopus citations


Relatively little is known about cognitive changes in early human immunodeficiency virus (HIV) infection. This study examined cognitive functioning in 46 HIV-positive gay men relative to an age and education equivalent group of 13 HIV-negative gay men. The HIV-positive men were asymptomatic except for lymphadenopathy or T4 counts less than 700. The cognitive battery measured language, memory, visuospatial, information processing speeds, reasoning, attention, and psychomotor processes. The HIV-positive group was significantly slower in processing information and performed significantly less well than the HIV-negative group on certain verbal memory measures. Deviations of 1 as well as 2 SDs from the norm/control group mean on four or more tests were observed in 43% and 22% of the HIV-positive subjects, respectively, compared with 8% and none of the HIV-negative subjects, respectively. The results suggest that cognitive inefficiency occurs in a sub-sample of individuals during early HIV infection.

Original languageEnglish (US)
Pages (from-to)433-440
Number of pages8
JournalArchives of neurology
Issue number4
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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