Cognition in early human immunodeficiency virus infection

F. L. Wilkie, C. Eisdorfer, David Loewenstein, Jose Szapocznik, J. Szapocznik

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Relatively little is known about cognitive changes in early human immunodeficiency virus (HIV) infection. This study examined cognitive functioning in 46 HIV-positive gay men relative to an age and education equivalent group of 13 HIV-negative gay men. The HIV-positive men were asymptomatic except for lymphadenopathy or T4 counts less than 700. The cognitive battery measured language, memory, visuospatial, information processing speeds, reasoning, attention, and psychomotor processes. The HIV-positive group was significantly slower in processing information and performed significantly less well than the HIV-negative group on certain verbal memory measures. Deviations of 1 as well as 2 SDs from the norm/control group mean on four or more tests were observed in 43% and 22% of the HIV-positive subjects, respectively, compared with 8% and none of the HIV-negative subjects, respectively. The results suggest that cognitive inefficiency occurs in a sub-sample of individuals during early HIV infection.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalArchives of Neurology
Volume47
Issue number4
StatePublished - Jan 1 1990

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Virus Diseases
Cognition
HIV
Automatic Data Processing
AIDS/HIV
Language
Education
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wilkie, F. L., Eisdorfer, C., Loewenstein, D., Szapocznik, J., & Szapocznik, J. (1990). Cognition in early human immunodeficiency virus infection. Archives of Neurology, 47(4), 433-440.

Cognition in early human immunodeficiency virus infection. / Wilkie, F. L.; Eisdorfer, C.; Loewenstein, David; Szapocznik, Jose; Szapocznik, J.

In: Archives of Neurology, Vol. 47, No. 4, 01.01.1990, p. 433-440.

Research output: Contribution to journalArticle

Wilkie, FL, Eisdorfer, C, Loewenstein, D, Szapocznik, J & Szapocznik, J 1990, 'Cognition in early human immunodeficiency virus infection', Archives of Neurology, vol. 47, no. 4, pp. 433-440.
Wilkie, F. L. ; Eisdorfer, C. ; Loewenstein, David ; Szapocznik, Jose ; Szapocznik, J. / Cognition in early human immunodeficiency virus infection. In: Archives of Neurology. 1990 ; Vol. 47, No. 4. pp. 433-440.
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