Cognition and immune function in HIV-1 infection

Frances L. Wilkie, Robert Morgan, Mary Ann Fletcher, Nancy Blaney, Marianna Baum, Eugene Komaroff, Jose Szapocznik, Carl Eisdorfer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objectives: To determine (1) whether there were differences in cognition between HIV-1-seropositive and HIV-1-seronegative homosexual men and (2), if so, whether these differences could be explained by the degree of immunosuppression [i.e., CD4 cell count and immunoglobulin A (IgA) levels]. Design: A cross-sectional design was used to compare 66 HIV-1-seropositives (Centers for Disease Control stages II and III, n = 56; stages IVA and IVC-2, n = 10) and 37 HIV-1-seronegatives. The HIV-1-seropositives were classified into three immune groups based on their CD4 cell count (× 106/I) and serum IgA level (mg/dl): (1) moderate [(n = 35) CD4 > 400, IgA < 300]; (2) mixed [(n = 22) either CD4 > 400 and IgA > 300 or CD4 < 400 and IgA < 300] and (3) poor [(n = 9) CD4 < 400, IgA > 300]. HIV-1-seronegatives formed the 'good' immune group (CD4 > 400 and IgA < 300). Methods: The four groups were compared on tests of verbal and visual memory, information-processing speeds, visuospatial skills, language processes, attention, psychomotor reaction time, and mental status. Factors other than HIV-1 serostatus that can influence cognitive performance were tested as covariates. Results: HIV-1-seropositives had slower information-processing speeds and decreased verbal and visual memory, compared with HIV-1-seronegatives. These differences in cognition were not due to differential immunosuppression or to clinical status among the HIV-1-seropositives. Conclusions: Cognitive alterations occur in HIV-1-infected individuals before AIDS and appear to be independent of clinical status and degree of immunosuppression as measured by CD4 cell count and IgA levels.

Original languageEnglish
Pages (from-to)977-981
Number of pages5
JournalAIDS
Volume6
Issue number9
StatePublished - Sep 1 1992

Fingerprint

Cognition
HIV Infections
HIV-1
Immunoglobulin A
CD4 Lymphocyte Count
Immunosuppression
Automatic Data Processing
Centers for Disease Control and Prevention (U.S.)
Reaction Time
Acquired Immunodeficiency Syndrome
Language

Keywords

  • CD4 cell count
  • Cognition
  • HIV-1 infection
  • Homosexual men
  • Immunoglobulin A level
  • Neuropsychology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Wilkie, F. L., Morgan, R., Fletcher, M. A., Blaney, N., Baum, M., Komaroff, E., ... Eisdorfer, C. (1992). Cognition and immune function in HIV-1 infection. AIDS, 6(9), 977-981.

Cognition and immune function in HIV-1 infection. / Wilkie, Frances L.; Morgan, Robert; Fletcher, Mary Ann; Blaney, Nancy; Baum, Marianna; Komaroff, Eugene; Szapocznik, Jose; Eisdorfer, Carl.

In: AIDS, Vol. 6, No. 9, 01.09.1992, p. 977-981.

Research output: Contribution to journalArticle

Wilkie, FL, Morgan, R, Fletcher, MA, Blaney, N, Baum, M, Komaroff, E, Szapocznik, J & Eisdorfer, C 1992, 'Cognition and immune function in HIV-1 infection', AIDS, vol. 6, no. 9, pp. 977-981.
Wilkie FL, Morgan R, Fletcher MA, Blaney N, Baum M, Komaroff E et al. Cognition and immune function in HIV-1 infection. AIDS. 1992 Sep 1;6(9):977-981.
Wilkie, Frances L. ; Morgan, Robert ; Fletcher, Mary Ann ; Blaney, Nancy ; Baum, Marianna ; Komaroff, Eugene ; Szapocznik, Jose ; Eisdorfer, Carl. / Cognition and immune function in HIV-1 infection. In: AIDS. 1992 ; Vol. 6, No. 9. pp. 977-981.
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