Children with epilepsy often manifest comorbid conditions, some causally related to the seizure activity (eg, congenital malformation, injury, metabolic disturbance, tumors) and others due to the epilepsy treatment (eg, behavioral complications due to antiepileptic drugs [AEDs]). Repeated seizure activity is associated with cognitive regression, behavioral disturbance, social disability, and sleep disorders - conditions that may be difficult to recognize in children with epilepsy and other developmental disorders (eg, mental retardation, cerebral palsy, autism) and that coexist in a high proportion of cases. Prompt recognition and treatment of these coexisting disorders is critical to achieving the best seizure control and overall quality of life for patients and their families. The potential for treatment-related disorders must also be carefully considered in this population. Clinicians should be aware of the range of adverse effects of AEDs (eg, behavioral, gastrointestinal, hematologic, neurologic, and renal) and be prepared to reevaluate treatment options as necessary.
|Original language||English (US)|
|Journal||Advanced Studies in Medicine|
|Issue number||7 B|
|State||Published - Jul 1 2003|
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