Coexistence of primary antiphospholipid syndrome and protein S deficiency in a Hispanic man with ischemic stroke

Yolanda Reyes-Iglesias, Arturo A. Ortiz, Dario M. Goitía, Rafael Meléndez

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The primary antiphospholipid syndrome and protein S deficiency are known hypercoagulable states predisposing to ischemic strokes. The pathogenesis of those hypercoagulable states has been independently studied and, recently, interaction between them has been proposed. A 48-year-old Hispanic man had generalized seizures 5 months after the acute onset of a left middle cerebral artery infract. He had a strong family history of strokes. After evaluation for cardiology, rheumatologic, hematologic and metabolic etiologies for strokes, anticardiolipin antibodies and protein S deficiency were detected. Cerebral angiography was normal. First degree relatives were evaluated and screened for these conditions. Lupus anticoagulant was detected in a sister who reported a transient hemisensory deficit. None of the relatives studied had clinical or laboratory criteria for collagen vascular deseases. Coexistence of the primary antiphospholipid syndrome and protein S deficiency, two known prothombotic states, has rarely been reported in Hispanic adults in association with ischemic stroke.

Original languageEnglish (US)
Pages (from-to)296-298
Number of pages3
JournalSouthern medical journal
Volume91
Issue number3
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Medicine(all)

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