Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K. Bhattacharya, Suresh P. Annangudi, Robert G. Salomon, Rachel W. Kuchtey, Neal S. Peachey, John W. Crabb

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

Original languageEnglish (US)
Pages (from-to)741-744
Number of pages4
JournalExperimental Eye Research
Volume80
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Cochlin
  • Elevated intraocular pressure
  • Glaucoma
  • Optic nerve damage
  • Trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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    Bhattacharya, S. K., Annangudi, S. P., Salomon, R. G., Kuchtey, R. W., Peachey, N. S., & Crabb, J. W. (2005). Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse. Experimental Eye Research, 80(5), 741-744. https://doi.org/10.1016/j.exer.2005.01.028