Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K. Bhattacharya; Suresh P. Annangudi; Robert G. Salomon; Rachel W. Kuchtey; Neal S. Peachey; John W. Crabb

doi:10.1016/j.exer.2005.01.028

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K. Bhattacharya, Suresh P. Annangudi, Robert G. Salomon, Rachel W. Kuchtey, Neal S. Peachey, John W. Crabb

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

Original language	English (US)
Pages (from-to)	741-744
Number of pages	4
Journal	Experimental Eye Research
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.exer.2005.01.028
State	Published - May 2005
Externally published	Yes

Keywords

Cochlin
Elevated intraocular pressure
Glaucoma
Optic nerve damage
Trabecular meshwork

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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Bhattacharya, S. K., Annangudi, S. P., Salomon, R. G., Kuchtey, R. W., Peachey, N. S., & Crabb, J. W. (2005). Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse. Experimental Eye Research, 80(5), 741-744. https://doi.org/10.1016/j.exer.2005.01.028

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title = "Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse",

abstract = "Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.",

keywords = "Cochlin, Elevated intraocular pressure, Glaucoma, Optic nerve damage, Trabecular meshwork",

author = "Bhattacharya, {Sanjoy K.} and Annangudi, {Suresh P.} and Salomon, {Robert G.} and Kuchtey, {Rachel W.} and Peachey, {Neal S.} and Crabb, {John W.}",

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AU - Bhattacharya, Sanjoy K.

AU - Annangudi, Suresh P.

AU - Salomon, Robert G.

AU - Kuchtey, Rachel W.

AU - Peachey, Neal S.

AU - Crabb, John W.

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AB - Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

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