Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K. Bhattacharya; Suresh P. Annangudi; Robert G. Salomon; Rachel W. Kuchtey; Neal S. Peachey; John W. Crabb

doi:10.1016/j.exer.2005.01.028

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K. Bhattacharya, Suresh P. Annangudi, Robert G. Salomon, Rachel W. Kuchtey, Neal S. Peachey, John W. Crabb

Ophthalmology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

Original language	English (US)
Pages (from-to)	741-744
Number of pages	4
Journal	Experimental Eye Research
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.exer.2005.01.028
State	Published - May 2005

Keywords

Cochlin
Elevated intraocular pressure
Glaucoma
Optic nerve damage
Trabecular meshwork

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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@article{0b60e6ef51a5451c9d74e5bdc6b063e4,

title = "Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse",

abstract = "Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.",

keywords = "Cochlin, Elevated intraocular pressure, Glaucoma, Optic nerve damage, Trabecular meshwork",

author = "Bhattacharya, {Sanjoy K.} and Annangudi, {Suresh P.} and Salomon, {Robert G.} and Kuchtey, {Rachel W.} and Peachey, {Neal S.} and Crabb, {John W.}",

note = "Funding Information: This study was supported in part by the National Glaucoma Research Program of American Health Assistance Foundation (SKB), NIH grants EY6603 (JWC), EY14239 (JWC), EY015638 (JWC), GM 21249 (RGS), Medical Research Service, Department of Veterans Affairs (NSP), a Research Center Grant from The Foundation Fighting Blindness (JWC), and funds from the Cleveland Clinic Foundation (JWC). We thank Ms Marg Esser for assistance with quantitative Western analysis. We are grateful to Professor Cynthia Morton for generously providing anti-cochlin antibody.",

year = "2005",

month = may,

doi = "10.1016/j.exer.2005.01.028",

language = "English (US)",

volume = "80",

pages = "741--744",

journal = "Experimental Eye Research",

issn = "0014-4835",

publisher = "Academic Press Inc.",

number = "5",

}

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T1 - Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

AU - Bhattacharya, Sanjoy K.

AU - Annangudi, Suresh P.

AU - Salomon, Robert G.

AU - Kuchtey, Rachel W.

AU - Peachey, Neal S.

AU - Crabb, John W.

N1 - Funding Information: This study was supported in part by the National Glaucoma Research Program of American Health Assistance Foundation (SKB), NIH grants EY6603 (JWC), EY14239 (JWC), EY015638 (JWC), GM 21249 (RGS), Medical Research Service, Department of Veterans Affairs (NSP), a Research Center Grant from The Foundation Fighting Blindness (JWC), and funds from the Cleveland Clinic Foundation (JWC). We thank Ms Marg Esser for assistance with quantitative Western analysis. We are grateful to Professor Cynthia Morton for generously providing anti-cochlin antibody.

PY - 2005/5

Y1 - 2005/5

N2 - Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

AB - Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

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KW - Trabecular meshwork

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