Abstract
Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.
Original language | English (US) |
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Pages (from-to) | 741-744 |
Number of pages | 4 |
Journal | Experimental Eye Research |
Volume | 80 |
Issue number | 5 |
DOIs | |
State | Published - May 2005 |
Keywords
- Cochlin
- Elevated intraocular pressure
- Glaucoma
- Optic nerve damage
- Trabecular meshwork
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems