Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K Bhattacharya; Suresh P. Annangudi; Robert G. Salomon; Rachel W. Kuchtey; Neal S. Peachey; John W. Crabb

doi:10.1016/j.exer.2005.01.028

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Sanjoy K Bhattacharya, Suresh P. Annangudi, Robert G. Salomon, Rachel W. Kuchtey, Neal S. Peachey, John W. Crabb

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

Original language	English
Pages (from-to)	741-744
Number of pages	4
Journal	Experimental Eye Research
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.exer.2005.01.028
State	Published - May 1 2005
Externally published	Yes

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Keywords

Cochlin
Elevated intraocular pressure
Glaucoma
Optic nerve damage
Trabecular meshwork

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

Cite this

Bhattacharya, S. K., Annangudi, S. P., Salomon, R. G., Kuchtey, R. W., Peachey, N. S., & Crabb, J. W. (2005). Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse. Experimental Eye Research, 80(5), 741-744. https://doi.org/10.1016/j.exer.2005.01.028

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abstract = "Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.",

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AU - Salomon, Robert G.

AU - Kuchtey, Rachel W.

AU - Peachey, Neal S.

AU - Crabb, John W.

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AB - Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.

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Access to Document

10.1016/j.exer.2005.01.028