Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermia

Adrien Eshraghi, Omar Nehme, Marek Polak, Jiao He, Ofelia F. Alonso, W. Dalton Dietrich, Thomas J. Balkany, Thomas R Van De Water

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Conclusions. During systemic hypothermia, the internal temperature of the rat cochlea correlates best with the temporalis muscle and rectal temperatures. These positive correlations will be used in future studies to assess the efficacy of mild and moderate hypothermia to protect hearing against the progressive loss caused by electrode insertion in a clinically relevant model of cochlear implantation trauma. Objective. To monitor the internal temperature of the cochlea during induced systemic hypothermia using a reference tissue instead of an internal cochlear temperature probe. Material and methods. The temperatures of the cochlea, brain, temporalis muscle and rectum were determined during periods of normothermia (37°C), mild (33°C) and moderate (30°C) hypothermia and slow rewarming in anesthetized adult Fisher rats. These values were compared using statistical analysis to establish the best correlations between the temperature of the cochlea and the temperature at the three other temperature measurement sites. Results. The strongest correlations with the internal temperature of the cochlea during the induction of mild-to-moderate hypothermia were obtained for the temperatures of the ipsilateral temporalis muscle and rectum.

Original languageEnglish
Pages (from-to)922-928
Number of pages7
JournalActa Oto-Laryngologica
Volume125
Issue number9
DOIs
StatePublished - Sep 23 2005

Fingerprint

Cochlea
Hypothermia
Muscles
Temperature
Rectum
Induced Hypothermia
Cochlear Implantation
Rewarming
Hearing
Electrodes

Keywords

  • Cochlear damage
  • Cochlear implantation
  • Hearing
  • Internal cochlear temperature
  • Otoprotection
  • Temperature correlations

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermia. / Eshraghi, Adrien; Nehme, Omar; Polak, Marek; He, Jiao; Alonso, Ofelia F.; Dalton Dietrich, W.; Balkany, Thomas J.; Van De Water, Thomas R.

In: Acta Oto-Laryngologica, Vol. 125, No. 9, 23.09.2005, p. 922-928.

Research output: Contribution to journalArticle

Eshraghi, Adrien ; Nehme, Omar ; Polak, Marek ; He, Jiao ; Alonso, Ofelia F. ; Dalton Dietrich, W. ; Balkany, Thomas J. ; Van De Water, Thomas R. / Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermia. In: Acta Oto-Laryngologica. 2005 ; Vol. 125, No. 9. pp. 922-928.
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