Cochlear implantation trauma and noise-induced hearing loss: Apoptosis and therapeutic strategies

Adrien A. Eshraghi, Thomas R. Van De Water

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Cochlear implantation trauma and noise-induced hearing loss both involve a physical disruption of the organ of Corti and may involve several mechanisms of cell death at the molecular level, i.e., necrosis, necrosis-like programmed cell death (PCD; type 2 PCD), and apoptosis (type 1 PCD). This article reviews several promising therapeutic strategies that are currently being developed. One of these promising new strategies involves the use of a highly effective peptide inhibitor of the c-Jun N-terminal kinase cell death signal cascade (i.e., D-JNKI-1) to prevent apoptosis of injured auditory hair cells. Our recent studies showed prevention of cochlear implantation-induced hearing loss by infusing this peptide into the cochlea of guinea pigs. Another otoprotective therapy under investigation is the application of mild hypothermia to protect the cochlea from the development of a hearing loss that follows exposure to a physical trauma, e.g., electrode array insertional trauma. These forward-looking strategies have the potential of improving hearing outcomes after cochlear implantation and providing novel means of otoprotection from noise-induced trauma.

Original languageEnglish (US)
Pages (from-to)473-481
Number of pages9
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume288
Issue number4
DOIs
StatePublished - Apr 1 2006

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Keywords

  • Apoptosis
  • Cell death signal cascades
  • Cochlear implant
  • Electrode insertion trauma
  • Hearing loss
  • Necrosis
  • Otoprotection
  • Sound trauma

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

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