Cochlear implantation in a patient with profound hearing loss with the A1555G mitochondrial DNA mutation and no history of aminoglycoside exposure

S. Arif Ulubil, Alexis D. Furze, Simon I Angeli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The A1555G mitochondrial deoxyribonucleic acid (mtDNA) point mutation has classically been associated with sensorineural hearing loss in patients following aminoglycoside exposure. More recently, the mutation has been implicated in sensorineural hearing loss in patients without previous aminoglycoside use. In addition, cochlear implantation has been shown to be effective in the group of patients with prior aminoglycoside exposure but, to date, no case of cochlear implantation in a patient with the A1555G mutation and no prior exposure to aminoglycosides has been explicitly described in the literature. We report the case of an 80-year-old woman with the A1555G mtDNA mutation, a 35-year history of bilateral progressive hearing loss and no history of aminoglycoside exposure who underwent successful implantation of a Nucleus 24 Contour device at our institution. Post-operatively, the patient exhibited marked improvement in tests of auditory performance. We conclude that cochlear implantation can be an effective method to restore some sense of hearing in patients with the A1555G mtDNA mutation and sensorineural hearing loss.

Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalJournal of Laryngology and Otology
Volume120
Issue number3
DOIs
StatePublished - Mar 1 2006

Fingerprint

Cochlear Implantation
Aminoglycosides
Mitochondrial DNA
Hearing Loss
Mutation
Sensorineural Hearing Loss
DNA
Bilateral Hearing Loss
Point Mutation
Hearing
Equipment and Supplies

Keywords

  • Cochlear Implants
  • DNA, Mitochondrial
  • Hearing Loss, Sensorineural
  • Mutation

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cochlear implantation in a patient with profound hearing loss with the A1555G mitochondrial DNA mutation and no history of aminoglycoside exposure. / Ulubil, S. Arif; Furze, Alexis D.; Angeli, Simon I.

In: Journal of Laryngology and Otology, Vol. 120, No. 3, 01.03.2006, p. 230-232.

Research output: Contribution to journalArticle

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