Cochlear function in mice following inhalation of brevetoxin-3

Janet M. Benson, Barden B. Stagner, Glen K. Martin, Melissa Friedman, Sarah E. Durr, Andrea Gomez, Jacob McDonald, Lora E. Fleming, Lorraine C. Backer, Daniel G. Baden, Andrea Bourdelais, Jerome Naar, Brenda L. Lonsbury-Martin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f 1-f 2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Volume191
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • Brevetoxin
  • CBA/CaJ mice
  • Cochlear function
  • Distortion-product otoacoustic emissions

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience
  • Neuroscience(all)

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    Benson, J. M., Stagner, B. B., Martin, G. K., Friedman, M., Durr, S. E., Gomez, A., McDonald, J., Fleming, L. E., Backer, L. C., Baden, D. G., Bourdelais, A., Naar, J., & Lonsbury-Martin, B. L. (2005). Cochlear function in mice following inhalation of brevetoxin-3. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 191(7), 619-626. https://doi.org/10.1007/s00359-005-0613-0