Cochlear function in mice following inhalation of brevetoxin-3

Janet M. Benson, Barden B. Stagner, Glen K. Martin, Melissa Friedman, Sarah E. Durr, Andrea Gomez, Jacob McDonald, Lora E. Fleming, Lorraine C. Backer, Daniel G. Baden, Andrea Bourdelais, Jerome Naar, Brenda L. Lonsbury-Martin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f 1-f 2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Volume191
Issue number7
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

brevetoxins
Cochlea
Inhalation
breathing
mice
Inbred CBA Mouse
Goldfish
Nose
goldfish
brevetoxin 3
effect
exposure
product
dosage

Keywords

  • Brevetoxin
  • CBA/CaJ mice
  • Cochlear function
  • Distortion-product otoacoustic emissions

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience
  • Neuroscience(all)

Cite this

Benson, J. M., Stagner, B. B., Martin, G. K., Friedman, M., Durr, S. E., Gomez, A., ... Lonsbury-Martin, B. L. (2005). Cochlear function in mice following inhalation of brevetoxin-3. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 191(7), 619-626. https://doi.org/10.1007/s00359-005-0613-0

Cochlear function in mice following inhalation of brevetoxin-3. / Benson, Janet M.; Stagner, Barden B.; Martin, Glen K.; Friedman, Melissa; Durr, Sarah E.; Gomez, Andrea; McDonald, Jacob; Fleming, Lora E.; Backer, Lorraine C.; Baden, Daniel G.; Bourdelais, Andrea; Naar, Jerome; Lonsbury-Martin, Brenda L.

In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, Vol. 191, No. 7, 01.07.2005, p. 619-626.

Research output: Contribution to journalArticle

Benson, JM, Stagner, BB, Martin, GK, Friedman, M, Durr, SE, Gomez, A, McDonald, J, Fleming, LE, Backer, LC, Baden, DG, Bourdelais, A, Naar, J & Lonsbury-Martin, BL 2005, 'Cochlear function in mice following inhalation of brevetoxin-3', Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, vol. 191, no. 7, pp. 619-626. https://doi.org/10.1007/s00359-005-0613-0
Benson, Janet M. ; Stagner, Barden B. ; Martin, Glen K. ; Friedman, Melissa ; Durr, Sarah E. ; Gomez, Andrea ; McDonald, Jacob ; Fleming, Lora E. ; Backer, Lorraine C. ; Baden, Daniel G. ; Bourdelais, Andrea ; Naar, Jerome ; Lonsbury-Martin, Brenda L. / Cochlear function in mice following inhalation of brevetoxin-3. In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 2005 ; Vol. 191, No. 7. pp. 619-626.
@article{fcf22e1b665541a3b385cb714407423d,
title = "Cochlear function in mice following inhalation of brevetoxin-3",
abstract = "Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f 1-f 2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.",
keywords = "Brevetoxin, CBA/CaJ mice, Cochlear function, Distortion-product otoacoustic emissions",
author = "Benson, {Janet M.} and Stagner, {Barden B.} and Martin, {Glen K.} and Melissa Friedman and Durr, {Sarah E.} and Andrea Gomez and Jacob McDonald and Fleming, {Lora E.} and Backer, {Lorraine C.} and Baden, {Daniel G.} and Andrea Bourdelais and Jerome Naar and Lonsbury-Martin, {Brenda L.}",
year = "2005",
month = "7",
day = "1",
doi = "10.1007/s00359-005-0613-0",
language = "English",
volume = "191",
pages = "619--626",
journal = "Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology",
issn = "0340-7594",
publisher = "Springer Verlag",
number = "7",

}

TY - JOUR

T1 - Cochlear function in mice following inhalation of brevetoxin-3

AU - Benson, Janet M.

AU - Stagner, Barden B.

AU - Martin, Glen K.

AU - Friedman, Melissa

AU - Durr, Sarah E.

AU - Gomez, Andrea

AU - McDonald, Jacob

AU - Fleming, Lora E.

AU - Backer, Lorraine C.

AU - Baden, Daniel G.

AU - Bourdelais, Andrea

AU - Naar, Jerome

AU - Lonsbury-Martin, Brenda L.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f 1-f 2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.

AB - Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f 1-f 2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (∼400 μg/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels.

KW - Brevetoxin

KW - CBA/CaJ mice

KW - Cochlear function

KW - Distortion-product otoacoustic emissions

UR - http://www.scopus.com/inward/record.url?scp=23744476443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744476443&partnerID=8YFLogxK

U2 - 10.1007/s00359-005-0613-0

DO - 10.1007/s00359-005-0613-0

M3 - Article

C2 - 15902474

AN - SCOPUS:23744476443

VL - 191

SP - 619

EP - 626

JO - Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology

JF - Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology

SN - 0340-7594

IS - 7

ER -