Cocaine-induced conditioned place preference in mice: Induction, extinction and reinstatement by related psychostimulants

Yossef Itzhak, Julio L. Martin

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Reinstatement of drug-seeking behavior in animals is relevant to drug relapse in humans. In the present study, we employed the conditioned place preference (CPP) paradigm to investigate the extinction and reinstatement of the place-conditioned response, a model that is consistent with drug-seeking behavior. Cocaine-induced CPP was rendered in Swiss Webster mice and then extinguished after repeated saline injections (8 days) in both the previously cocaine-paired compartment and the saline-paired compartment. Following the extinction phase, the reinstatement of CPP was investigated. Cocaine-experienced mice were challenged with one of the following psychostimulants, cocaine (15 mg/kg), methamphetamine (METH; 0.5 mg/kg), methylphenidate (MPD; 20 mg/kg) and phencyclidine (PCP; 5 mg/kg). The priming injection of cocaine, METH and MPD, unlike PCP, induced a marked preference for the previously cocaine-paired compartment. This finding suggests that all three psychostimulants reinstated the CPP response, and METH and MPD substituted for the reinforcing cue of cocaine. A challenge injection of cocaine administered two and four weeks after the reinstatement of CPP indicated that CPP was maintained up to two weeks. The finding that METH and MPD but not PCP reinstated and supported cocaine-induced CPP suggests that the CPP paradigm may be a useful tool for drug discrimination studies and the reinstatement of drug-seeking behavior.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalNeuropsychopharmacology
Volume26
Issue number1
DOIs
StatePublished - Jan 29 2002

Fingerprint

Cocaine
Drug-Seeking Behavior
Injections
Psychological Extinction
Phencyclidine
Methylphenidate
Methamphetamine
Pharmaceutical Preparations
Cues
Recurrence

Keywords

  • Cocaine
  • Conditioned place preference
  • Methamphetamine
  • Methylphenidate
  • Phencyclidine
  • Reward

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cocaine-induced conditioned place preference in mice : Induction, extinction and reinstatement by related psychostimulants. / Itzhak, Yossef; Martin, Julio L.

In: Neuropsychopharmacology, Vol. 26, No. 1, 29.01.2002, p. 130-134.

Research output: Contribution to journalArticle

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