Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats

Stephanie L. Collins, Sari E Izenwasser

Research output: Contribution to journalArticle

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Abstract

This study examined whether there are differences in the behavioral and neurochemical effects of cocaine in periadolescent rats compared to adult rats. Periadolescent (postnatal days 28-35) and adult rats were injected with cocaine or vehicle for 7 days. Ten days later (day 17), rats either were challenged with cocaine, or dopamine transporter and receptor and serotonin transporter binding were examined. Adult rats became sensitized to the locomotor-activating effects of cocaine and there were increases in dopamine transporter density in the caudate putamen compared to vehicle-treated adult rats. In addition, serotonin transporter densities were increased in the ventromedial caudate putamen, nucleus accumbens shell, and the olfactory tubercle in cocaine-treated adult rats compared to vehicle-treated adult rats. In contrast, periadolescent rats did not show sensitization to cocaine and there was no effect of cocaine on either dopamine or serotonin transporter densities. These findings suggest that there are different neurochemical and behavioral adaptations to repeated cocaine administration in periadolescent versus adult rats.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalDevelopmental Brain Research
Volume138
Issue number1
DOIs
StatePublished - Sep 20 2002

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Neurochemistry
Cocaine
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Putamen
Caudate Nucleus
Dopamine Receptors
Nucleus Accumbens

Keywords

  • Adolescence
  • Autoradiography
  • Cocaine
  • Dopamine
  • Locomotor activity
  • Sensitization
  • Serotonin

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats. / Collins, Stephanie L.; Izenwasser, Sari E.

In: Developmental Brain Research, Vol. 138, No. 1, 20.09.2002, p. 27-34.

Research output: Contribution to journalArticle

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