Cocaine dependence treatment data: Methods for measurement error problems with predictors derived from stationary stochastic processes

Yongtao Guan, Yehua Li, Rajita Sinha

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In a cocaine dependence treatment study, we use linear and nonlinear regression models to model posttreatment cocaine craving scores and first cocaine relapse time. A subset of the covariates are summary statistics derived from baseline daily cocaine use trajectories, such as baseline cocaine use frequency and average daily use amount. These summary statistics are subject to estimation error and can therefore cause biased estimators for the regression coefficients. Unlike classical measurement error problems, the error we encounter here is heteroscedastic with an unknown distribution, and there are no replicates for the error-prone variables or instrumental variables. We propose two robust methods to correct for the bias: a computationally efficient method-of-moments-based method for linear regression models and a subsampling extrapolation method that is generally applicable to both linear and nonlinear regression models. Simulations and an application to the cocaine dependence treatment data are used to illustrate the efficacy of the proposed methods. Asymptotic theory and variance estimation for the proposed subsampling extrapolation method and some additional simulation results are described in the online supplementary material.

Original languageEnglish (US)
Pages (from-to)480-493
Number of pages14
JournalJournal of the American Statistical Association
Volume106
Issue number494
DOIs
StatePublished - Jun 2011

Keywords

  • Bias correction
  • Method-of-moments correction
  • Subsampling extrapolation

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

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