Cocaine and several σ receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several σ receptor ligands have been shown to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse.
- Dopamine uptake
- [H]CFT ([H]2β-carbomethoxy-3β-(4-fluoro-phenyl)-tropane, [H]WIN 35,428)
- σ Receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience