Cocaine and several σ receptor ligands inhibit dopamine uptake in rat caudate-putamen

Sari Izenwasser, Amy Hauck Newman, Jonathan L. Katz

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Cocaine and several σ receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several σ receptor ligands have been shown to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalEuropean Journal of Pharmacology
Volume243
Issue number2
DOIs
StatePublished - Oct 19 1993
Externally publishedYes

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Keywords

  • Caudate-putamen
  • Cocaine
  • Dopamine uptake
  • Rimcazole
  • [H]CFT ([H]2β-carbomethoxy-3β-(4-fluoro-phenyl)-tropane, [H]WIN 35,428)
  • σ Receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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