Cocaine abuse and HIV-1 infection: Epidemiology and neuropathogenesis

Karl Goodkin, Paul Shapshak, Lisa R. Metsch, Clyde B. McCoy, Keith A. Crandall, Mahendra Kumar, Robert K. Fujimura, Virginia McCoy, Bao Tong Zhang, Svetlana Reyblat, Ke Qin Xin, Adarsh M. Kumar

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The epidemiology of cocaine abuse and potential relationships of cocaine withdrawal to human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are discussed. Neuroendocrinological changes in HIV-1 infection of the central nervous system (CNS) are discussed with the relevant impact of cocaine abuse. HIV-1 load in the brain tissue of infected substance users is described along with possible associations with neuropathology and HAD. Finally, the molecular epidemiology and sequence heterogeneity of HIV-1 and their implications for neuropathogenesis are summarized. The complex context of addressing cocaine abuse in the setting of HIV-1 infection appears more tractable when decomposed into its components.

Original languageEnglish (US)
Pages (from-to)88-101
Number of pages14
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Mar 15 1998


  • AIDS
  • Cocaine withdrawal
  • HIV-1
  • HIV-1-associated dementia (HAD)
  • Substance abuse
  • Virus load

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology


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