Coagulation abnormalities following thermal injury

Research output: Contribution to journalArticle

24 Citations (Scopus)


Changes in coagulation may have a profound impact on outcomes following severe burns and the coagulation abnormalities after thermal injury are incompletely described. We postulated that thermal injury induces a systemic hypercoagulable state. With Institutional Review Board approval, five patients were consented for enrollment in this case series. After obtaining informed consent, blood was drawn on hospital days 1, 2, 3, 5, and 7 or until discharge if discharge was in less than 7 days. Standard coagulation testing was performed, as well as a battery of sophisticated specialized coagulation assays. Other data collected includes fluid resuscitation volumes, pharmacologic interventions, and general physiologic information. Results (n = 5) demonstrate that burns less than 6% total body surface area appear to have little effect on coagulation. Burns greater than 6% appear to induce a systemic hypercoagulable state with a phase and magnitude relationship proportional to total body surface area burned. Severe burns greater than 40% appear to induce a consumptive coagulopathy. Prothrombin fragment 1.2 may represent a useful screening test for a burn-induced hypercoagulable state.

Original languageEnglish
Pages (from-to)666-669
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Issue number7
StatePublished - Oct 1 2010


Hot Temperature
Wounds and Injuries
Body Surface Area
Research Ethics Committees
Informed Consent


  • burns
  • fibrinolysis
  • hypercoagulable state
  • prothrombin
  • trauma

ASJC Scopus subject areas

  • Hematology

Cite this

Coagulation abnormalities following thermal injury. / King, David R.; Namias, Nicholas; Andrews, David.

In: Blood Coagulation and Fibrinolysis, Vol. 21, No. 7, 01.10.2010, p. 666-669.

Research output: Contribution to journalArticle

title = "Coagulation abnormalities following thermal injury",
abstract = "Lippincott Williams & Wilkins.",
keywords = "burns, fibrinolysis, hypercoagulable state, prothrombin, trauma",
author = "King, {David R.} and Nicholas Namias and David Andrews",
year = "2010",
month = "10",
day = "1",
doi = "10.1097/MBC.0b013e32833ceb08",
language = "English",
volume = "21",
pages = "666--669",
journal = "Blood Coagulation and Fibrinolysis",
issn = "0957-5235",
publisher = "Lippincott Williams and Wilkins",
number = "7",



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AU - King, David R.

AU - Namias, Nicholas

AU - Andrews, David

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Lippincott Williams & Wilkins.

AB - Lippincott Williams & Wilkins.

KW - burns

KW - fibrinolysis

KW - hypercoagulable state

KW - prothrombin

KW - trauma

UR -

UR -

U2 - 10.1097/MBC.0b013e32833ceb08

DO - 10.1097/MBC.0b013e32833ceb08

M3 - Article

C2 - 20689402

AN - SCOPUS:77958157235

VL - 21

SP - 666

EP - 669

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

SN - 0957-5235

IS - 7

ER -