Coadministration of rifampin and itraconazole leads to undetectable levels of serum itraconazole

Joyce Drayton, Gordon Dickinson, Michael G. Rinaldi

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

SIR-Drugs that induce hepatic drug-metabolizing enzymes accelerate the metabolism of the triazole itraconazole. One prospective study has shown that coadministration of rifampin and itraconazole may lead to undetectable levels of serum itraconazole [I]. This coadministration was associated with therapeutic failures in two patients with coccidioidomycosis. We measured levels ofitraconazole after therapy with rifampin was discontinued for a patient with disseminated histoplasmosis and pulmonary tuberculosis who had received both medications. After rifampin was discontinued, the levels of itraconazole in the serum were measurable and clinical improvement occurred.

Original languageEnglish (US)
Pages (from-to)266-267
Number of pages2
JournalClinical Infectious Diseases
Volume18
Issue number2
DOIs
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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