Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

Chen Wu, Zhaolong Han, Shang Wang, Jiasong Li, Manmohan Singh, Chih Hao Liu, Salavat Aglyamov, Stanislav Emelianov, Fabrice Manns, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9307
ISBN (Print)9781628413977
DOIs
StatePublished - 2015
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Other

Other25th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Fingerprint

Elasticity Imaging Techniques
Crystalline Lens
rabbits
Lenses
Ultrasonics
lenses
Rabbits
Crystalline materials
physiology
elastic deformation
Acoustics
Elastic waves
Physiology
Elastic deformation
sound waves
elastic waves
surgery
Surgery
stiffness
Radiation

Keywords

  • acoustic radiation
  • biomechanical properties
  • crystalline lens
  • force
  • optical coherence elastography (OCE)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Wu, C., Han, Z., Wang, S., Li, J., Singh, M., Liu, C. H., ... Larin, K. V. (2015). Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9307). [930716] SPIE. https://doi.org/10.1117/12.2079532

Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes. / Wu, Chen; Han, Zhaolong; Wang, Shang; Li, Jiasong; Singh, Manmohan; Liu, Chih Hao; Aglyamov, Salavat; Emelianov, Stanislav; Manns, Fabrice; Larin, Kirill V.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9307 SPIE, 2015. 930716.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wu, C, Han, Z, Wang, S, Li, J, Singh, M, Liu, CH, Aglyamov, S, Emelianov, S, Manns, F & Larin, KV 2015, Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9307, 930716, SPIE, 25th Conference on Ophthalmic Technologies, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2079532
Wu C, Han Z, Wang S, Li J, Singh M, Liu CH et al. Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9307. SPIE. 2015. 930716 https://doi.org/10.1117/12.2079532
Wu, Chen ; Han, Zhaolong ; Wang, Shang ; Li, Jiasong ; Singh, Manmohan ; Liu, Chih Hao ; Aglyamov, Salavat ; Emelianov, Stanislav ; Manns, Fabrice ; Larin, Kirill V. / Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9307 SPIE, 2015.
@inproceedings{51fd58b7fce24fe48f9afea506ed0d7e,
title = "Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes",
abstract = "In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.",
keywords = "acoustic radiation, biomechanical properties, crystalline lens, force, optical coherence elastography (OCE)",
author = "Chen Wu and Zhaolong Han and Shang Wang and Jiasong Li and Manmohan Singh and Liu, {Chih Hao} and Salavat Aglyamov and Stanislav Emelianov and Fabrice Manns and Larin, {Kirill V.}",
year = "2015",
doi = "10.1117/12.2079532",
language = "English (US)",
isbn = "9781628413977",
volume = "9307",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",

}

TY - GEN

T1 - Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

AU - Wu, Chen

AU - Han, Zhaolong

AU - Wang, Shang

AU - Li, Jiasong

AU - Singh, Manmohan

AU - Liu, Chih Hao

AU - Aglyamov, Salavat

AU - Emelianov, Stanislav

AU - Manns, Fabrice

AU - Larin, Kirill V.

PY - 2015

Y1 - 2015

N2 - In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

AB - In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

KW - acoustic radiation

KW - biomechanical properties

KW - crystalline lens

KW - force

KW - optical coherence elastography (OCE)

UR - http://www.scopus.com/inward/record.url?scp=84928527633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928527633&partnerID=8YFLogxK

U2 - 10.1117/12.2079532

DO - 10.1117/12.2079532

M3 - Conference contribution

SN - 9781628413977

VL - 9307

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

PB - SPIE

ER -