Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

Chen Wu, Zhaolong Han, Shang Wang, Jiasong Li, Manmohan Singh, Chih Hao Liu, Salavat Aglyamov, Stanislav Emelianov, Fabrice Manns, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we utilize a confocal ultrasound and phase-sensitive optical coherence elastography (OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in intact rabbit eyes in situ. Lowamplitude elastic deformations, induced on the surface of the lens by localized acoustic radiation force, were measured using phase-sensitive OCT. The results demonstrate that the displacements induced in young rabbit lenses are significantly larger than those in the mature lenses. Temporal analyses of the elastic waves are also demonstrated significant difference between young and old lenses, indicating that the stiffness of lens increases with the age. These results demonstrate possibility of OCE for completely noninvasive analysis and quantification of lens biomechanical properties, which could be used in many clinical and basic science applications such as surgeries and studies on lens physiology and function.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9307
ISBN (Print)9781628413977
DOIs
StatePublished - 2015
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Other

Other25th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Keywords

  • acoustic radiation
  • biomechanical properties
  • crystalline lens
  • force
  • optical coherence elastography (OCE)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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    Wu, C., Han, Z., Wang, S., Li, J., Singh, M., Liu, C. H., Aglyamov, S., Emelianov, S., Manns, F., & Larin, K. V. (2015). Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9307). [930716] SPIE. https://doi.org/10.1117/12.2079532