CNTF and retina

Rong Wen, Weng Tao, Yiwen Li, Paul A. Sieving

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia. In addition, CNTF is a neuroprotective factor and an axogenesis factor for retinal ganglion cells (RGCs). This review focuses on the effects of exogenous CNTF on photoreceptors and RGCs in the mammalian retina and the potential clinical application of CNTF for retinal degenerative diseases.

Original languageEnglish
Pages (from-to)136-151
Number of pages16
JournalProgress in Retinal and Eye Research
Volume31
Issue number2
DOIs
StatePublished - Mar 1 2012

Fingerprint

Ciliary Neurotrophic Factor
Retina
Retinal Cone Photoreceptor Cells
Retinal Ganglion Cells
Retinal Rod Photoreceptor Cells
Retinal Diseases
Nerve Growth Factors
Regeneration
Animal Models
Dogs

Keywords

  • CNTF
  • Neuroprotection
  • Photoreceptor plasticity
  • Photoreceptors
  • Retinal degeneration
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology

Cite this

CNTF and retina. / Wen, Rong; Tao, Weng; Li, Yiwen; Sieving, Paul A.

In: Progress in Retinal and Eye Research, Vol. 31, No. 2, 01.03.2012, p. 136-151.

Research output: Contribution to journalArticle

Wen, Rong ; Tao, Weng ; Li, Yiwen ; Sieving, Paul A. / CNTF and retina. In: Progress in Retinal and Eye Research. 2012 ; Vol. 31, No. 2. pp. 136-151.
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