CMV and Immunosenescence: From basics to clinics

Rafael Solana, Raquel Tarazona, Allison E. Aiello, Arne N. Akbar, Victor Appay, Mark Beswick, Jos A. Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein, Ann Hill, Mikko Hurme, Florian Kern, Anis LarbiMiguel López-Botet, Andrea B. Maier, Janet E. McElhaney, Paul Moss, Elissaveta Naumova, Janko Nikolich-Zugich, Alejandra Pera, Jerrald L. Rector, Natalie Riddell, Beatriz Sanchez-Correa, Paolo Sansoni, Delphine Sauce, Rene van Lier, George C. Wang, Mark R. Wills, Maciej Zieliński, Graham Pawelec

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates " immunosenescence" . This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

Original languageEnglish
Article number23
JournalImmunity and Ageing
Volume9
DOIs
StatePublished - Oct 31 2012

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Cytomegalovirus
Cytomegalovirus Infections
Education
Herpesviridae
Adaptive Immunity
Innate Immunity
Spain
T-Lymphocytes
Immunosenescence

ASJC Scopus subject areas

  • Immunology
  • Aging

Cite this

Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., ... Pawelec, G. (2012). CMV and Immunosenescence: From basics to clinics. Immunity and Ageing, 9, [23]. https://doi.org/10.1186/1742-4933-9-23

CMV and Immunosenescence : From basics to clinics. / Solana, Rafael; Tarazona, Raquel; Aiello, Allison E.; Akbar, Arne N.; Appay, Victor; Beswick, Mark; Bosch, Jos A.; Campos, Carmen; Cantisán, Sara; Cicin-Sain, Luka; Derhovanessian, Evelyna; Ferrando-Martínez, Sara; Frasca, Daniela; Fulöp, Tamas; Govind, Sheila; Grubeck-Loebenstein, Beatrix; Hill, Ann; Hurme, Mikko; Kern, Florian; Larbi, Anis; López-Botet, Miguel; Maier, Andrea B.; McElhaney, Janet E.; Moss, Paul; Naumova, Elissaveta; Nikolich-Zugich, Janko; Pera, Alejandra; Rector, Jerrald L.; Riddell, Natalie; Sanchez-Correa, Beatriz; Sansoni, Paolo; Sauce, Delphine; van Lier, Rene; Wang, George C.; Wills, Mark R.; Zieliński, Maciej; Pawelec, Graham.

In: Immunity and Ageing, Vol. 9, 23, 31.10.2012.

Research output: Contribution to journalArticle

Solana, R, Tarazona, R, Aiello, AE, Akbar, AN, Appay, V, Beswick, M, Bosch, JA, Campos, C, Cantisán, S, Cicin-Sain, L, Derhovanessian, E, Ferrando-Martínez, S, Frasca, D, Fulöp, T, Govind, S, Grubeck-Loebenstein, B, Hill, A, Hurme, M, Kern, F, Larbi, A, López-Botet, M, Maier, AB, McElhaney, JE, Moss, P, Naumova, E, Nikolich-Zugich, J, Pera, A, Rector, JL, Riddell, N, Sanchez-Correa, B, Sansoni, P, Sauce, D, van Lier, R, Wang, GC, Wills, MR, Zieliński, M & Pawelec, G 2012, 'CMV and Immunosenescence: From basics to clinics', Immunity and Ageing, vol. 9, 23. https://doi.org/10.1186/1742-4933-9-23
Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M et al. CMV and Immunosenescence: From basics to clinics. Immunity and Ageing. 2012 Oct 31;9. 23. https://doi.org/10.1186/1742-4933-9-23
Solana, Rafael ; Tarazona, Raquel ; Aiello, Allison E. ; Akbar, Arne N. ; Appay, Victor ; Beswick, Mark ; Bosch, Jos A. ; Campos, Carmen ; Cantisán, Sara ; Cicin-Sain, Luka ; Derhovanessian, Evelyna ; Ferrando-Martínez, Sara ; Frasca, Daniela ; Fulöp, Tamas ; Govind, Sheila ; Grubeck-Loebenstein, Beatrix ; Hill, Ann ; Hurme, Mikko ; Kern, Florian ; Larbi, Anis ; López-Botet, Miguel ; Maier, Andrea B. ; McElhaney, Janet E. ; Moss, Paul ; Naumova, Elissaveta ; Nikolich-Zugich, Janko ; Pera, Alejandra ; Rector, Jerrald L. ; Riddell, Natalie ; Sanchez-Correa, Beatriz ; Sansoni, Paolo ; Sauce, Delphine ; van Lier, Rene ; Wang, George C. ; Wills, Mark R. ; Zieliński, Maciej ; Pawelec, Graham. / CMV and Immunosenescence : From basics to clinics. In: Immunity and Ageing. 2012 ; Vol. 9.
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AU - Sanchez-Correa, Beatriz

AU - Sansoni, Paolo

AU - Sauce, Delphine

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