Abstract
This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.
| Original language | English |
|---|---|
| Title of host publication | Conference Proceedings of the International Symposium on Signals, Systems and Electronics |
| Pages | 37-40 |
| Number of pages | 4 |
| DOIs | |
| State | Published - Dec 1 2007 |
| Externally published | Yes |
| Event | 2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007 - Montreal, QC, Canada Duration: Jul 30 2007 → Aug 2 2007 |
Other
| Other | 2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007 |
|---|---|
| Country | Canada |
| City | Montreal, QC |
| Period | 7/30/07 → 8/2/07 |
Fingerprint
Keywords
- CMOS sensors
- Fluorescence
- Gratings
- Optical sensor
- Oxygen sensor
- Porous polymer
- Xerogels
ASJC Scopus subject areas
- Signal Processing
Cite this
CMOS microsystems for phase fluorometric biochemical monitoring. / Cartwright, Alexander N.; Chodavarapu, Vamsy P.; Kim, Sung Jin; Bukowski, Rachel M.; Titus, Albert H.; Bright, Frank V.
Conference Proceedings of the International Symposium on Signals, Systems and Electronics. 2007. p. 37-40 4294408.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - CMOS microsystems for phase fluorometric biochemical monitoring
AU - Cartwright, Alexander N.
AU - Chodavarapu, Vamsy P.
AU - Kim, Sung Jin
AU - Bukowski, Rachel M.
AU - Titus, Albert H.
AU - Bright, Frank V.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.
AB - This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.
KW - CMOS sensors
KW - Fluorescence
KW - Gratings
KW - Optical sensor
KW - Oxygen sensor
KW - Porous polymer
KW - Xerogels
UR - http://www.scopus.com/inward/record.url?scp=47349123779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47349123779&partnerID=8YFLogxK
U2 - 10.1109/ISSSE.2007.4294408
DO - 10.1109/ISSSE.2007.4294408
M3 - Conference contribution
AN - SCOPUS:47349123779
SN - 1424414490
SN - 9781424414499
SP - 37
EP - 40
BT - Conference Proceedings of the International Symposium on Signals, Systems and Electronics
ER -