CMOS microsystems for phase fluorometric biochemical monitoring

Alexander N. Cartwright, Vamsy P. Chodavarapu, Sung Jin Kim, Rachel M. Bukowski, Albert H. Titus, Frank V. Bright

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.

Original languageEnglish
Title of host publicationConference Proceedings of the International Symposium on Signals, Systems and Electronics
Pages37-40
Number of pages4
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007 - Montreal, QC, Canada
Duration: Jul 30 2007Aug 2 2007

Other

Other2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007
CountryCanada
CityMontreal, QC
Period7/30/078/2/07

Fingerprint

Microsystems
Monitoring
Sensors
Metals
Xerogels
Fluorescence
Fluorophores
Application specific integrated circuits
Excited states
Nanostructured materials
Photonics
Sol-gels
Glucose
Signal processing
Energy gap
Oxide semiconductors
Thin films
Oxygen
Polymers

Keywords

  • CMOS sensors
  • Fluorescence
  • Gratings
  • Optical sensor
  • Oxygen sensor
  • Porous polymer
  • Xerogels

ASJC Scopus subject areas

  • Signal Processing

Cite this

Cartwright, A. N., Chodavarapu, V. P., Kim, S. J., Bukowski, R. M., Titus, A. H., & Bright, F. V. (2007). CMOS microsystems for phase fluorometric biochemical monitoring. In Conference Proceedings of the International Symposium on Signals, Systems and Electronics (pp. 37-40). [4294408] https://doi.org/10.1109/ISSSE.2007.4294408

CMOS microsystems for phase fluorometric biochemical monitoring. / Cartwright, Alexander N.; Chodavarapu, Vamsy P.; Kim, Sung Jin; Bukowski, Rachel M.; Titus, Albert H.; Bright, Frank V.

Conference Proceedings of the International Symposium on Signals, Systems and Electronics. 2007. p. 37-40 4294408.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cartwright, AN, Chodavarapu, VP, Kim, SJ, Bukowski, RM, Titus, AH & Bright, FV 2007, CMOS microsystems for phase fluorometric biochemical monitoring. in Conference Proceedings of the International Symposium on Signals, Systems and Electronics., 4294408, pp. 37-40, 2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007, Montreal, QC, Canada, 7/30/07. https://doi.org/10.1109/ISSSE.2007.4294408
Cartwright AN, Chodavarapu VP, Kim SJ, Bukowski RM, Titus AH, Bright FV. CMOS microsystems for phase fluorometric biochemical monitoring. In Conference Proceedings of the International Symposium on Signals, Systems and Electronics. 2007. p. 37-40. 4294408 https://doi.org/10.1109/ISSSE.2007.4294408
Cartwright, Alexander N. ; Chodavarapu, Vamsy P. ; Kim, Sung Jin ; Bukowski, Rachel M. ; Titus, Albert H. ; Bright, Frank V. / CMOS microsystems for phase fluorometric biochemical monitoring. Conference Proceedings of the International Symposium on Signals, Systems and Electronics. 2007. pp. 37-40
@inproceedings{73ac3d12864f4110815e25cf11bd38bd,
title = "CMOS microsystems for phase fluorometric biochemical monitoring",
abstract = "This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.",
keywords = "CMOS sensors, Fluorescence, Gratings, Optical sensor, Oxygen sensor, Porous polymer, Xerogels",
author = "Cartwright, {Alexander N.} and Chodavarapu, {Vamsy P.} and Kim, {Sung Jin} and Bukowski, {Rachel M.} and Titus, {Albert H.} and Bright, {Frank V.}",
year = "2007",
month = "12",
day = "1",
doi = "10.1109/ISSSE.2007.4294408",
language = "English",
isbn = "1424414490",
pages = "37--40",
booktitle = "Conference Proceedings of the International Symposium on Signals, Systems and Electronics",

}

TY - GEN

T1 - CMOS microsystems for phase fluorometric biochemical monitoring

AU - Cartwright, Alexander N.

AU - Chodavarapu, Vamsy P.

AU - Kim, Sung Jin

AU - Bukowski, Rachel M.

AU - Titus, Albert H.

AU - Bright, Frank V.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.

AB - This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.

KW - CMOS sensors

KW - Fluorescence

KW - Gratings

KW - Optical sensor

KW - Oxygen sensor

KW - Porous polymer

KW - Xerogels

UR - http://www.scopus.com/inward/record.url?scp=47349123779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47349123779&partnerID=8YFLogxK

U2 - 10.1109/ISSSE.2007.4294408

DO - 10.1109/ISSSE.2007.4294408

M3 - Conference contribution

SN - 1424414490

SN - 9781424414499

SP - 37

EP - 40

BT - Conference Proceedings of the International Symposium on Signals, Systems and Electronics

ER -