CMOS microsystems for phase fluorometric biochemical monitoring

Alexander N. Cartwright, Vamsy P. Chodavarapu, Jin Kim Sung, Rachel M. Bukowski, Albert H. Titus, Frank V. Bright

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This article will present a review of our recent work on the development of Complementary Metal-Oxide Semiconductor (CMOS) detection and signal processing interfaces for fluorescence based biochemical sensors as well as the development of a new sensor. We will discuss a number of microsystems that integrate CMOS Application Specific Integrated Circuits (ASICs) with nanoporous sensor materials. Specifically, sol-gel derived xerogel thin films, a class of nanoporous materials, are employed for monitoring various biochemical analytes including oxygen (O2), glucose, and pH. We have also demonstrated a single-chip CMOS based phase fluorometric system for monitoring O2 using xerogel sensor materials. In this paper, we will present a new, versatile, CMOS based platform for real-time phase fluorometric analysis that is capable of functioning with fluorophores having excited-state lifetimes as short as 400 nanoseconds. In addition, we will describe the employment of novel nanomaterials (porous polymer photonic bandgap structures) as immobilization media for biochemical recognition elements that enhance the fluorescence detection efficiency. Finally, the development of integrated sensors using these materials will be described.

Original languageEnglish (US)
Title of host publication2007 International Symposium on Signals, Systems, and Electronics, URSI ISSSE 2007
Pages37-40
Number of pages4
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007 - Montreal, QC, Canada
Duration: Jul 30 2007Aug 2 2007

Publication series

NameConference Proceedings of the International Symposium on Signals, Systems and Electronics

Other

Other2007 International Symposium on Signals, Systems and Electronics, URSI ISSSE 2007
CountryCanada
CityMontreal, QC
Period7/30/078/2/07

    Fingerprint

Keywords

  • CMOS sensors
  • Fluorescence
  • Gratings
  • Optical sensor
  • Oxygen sensor
  • Porous polymer
  • Xerogels

ASJC Scopus subject areas

  • Signal Processing

Cite this

Cartwright, A. N., Chodavarapu, V. P., Sung, J. K., Bukowski, R. M., Titus, A. H., & Bright, F. V. (2007). CMOS microsystems for phase fluorometric biochemical monitoring. In 2007 International Symposium on Signals, Systems, and Electronics, URSI ISSSE 2007 (pp. 37-40). [4294408] (Conference Proceedings of the International Symposium on Signals, Systems and Electronics). https://doi.org/10.1109/ISSSE.2007.4294408