TY - JOUR
T1 - Clusters of perifollicular macrophages in normal murine skin
T2 - Physiological degeneration of selected hair follicles by programmed organ deletion
AU - Eichmüller, Stefan
AU - Van Der Veen, Carina
AU - Moll, Ingrid
AU - Hermes, Barbara
AU - Hofmann, Udo
AU - Müller-Röver, Sven
AU - Paus, Ralf
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1998/3
Y1 - 1998/3
N2 - In back skin sections from adolescent C57BL/6 mice, regularly distributed, perifollicular inflammatory cell clusters (PICC) were found located around the distal noncycling portion of about 2% of all hair follicles examined. The PICC and the affected hair follicles were characterized during spontaneously developed or induced hair cycle stages, using antibodies against MHC Class II,F4/80, ER-MP23, NLDC 145, CD4, CD8, γδTCR, IL-1 receptor, and ICAM-1. PICC consisted predominantly of macrophages (MAC), accompanied by a few CD4 cells, whereas γδTCR+ and CD8+ cells were absent. During anagen and catagen, some of the PICC hair follicles showed variable degenerative phenomena reminiscent of scarring alopecia: thickened basement membrane, ectopic MHC II expression, MAC infiltration into the follicle epithelium, and signs of keratinocyte apoptosis. Loss of distal outer root sheath keratinocytes was detected in 10% of PICC hair follicles (0.2% of all hair follicles). Because PICC were located in the vicinity of the bulge region, MAC-dependent damage to follicle stem cells might eventually lead to follicle degeneration. These perifollicular MAC clusters around selected hair follicles may indicate the existence of a physiological program of MAC dependent controlled follicle degeneration by which damaged or malfunctioning follicles are removed by programmed organ deletion (POD).
AB - In back skin sections from adolescent C57BL/6 mice, regularly distributed, perifollicular inflammatory cell clusters (PICC) were found located around the distal noncycling portion of about 2% of all hair follicles examined. The PICC and the affected hair follicles were characterized during spontaneously developed or induced hair cycle stages, using antibodies against MHC Class II,F4/80, ER-MP23, NLDC 145, CD4, CD8, γδTCR, IL-1 receptor, and ICAM-1. PICC consisted predominantly of macrophages (MAC), accompanied by a few CD4 cells, whereas γδTCR+ and CD8+ cells were absent. During anagen and catagen, some of the PICC hair follicles showed variable degenerative phenomena reminiscent of scarring alopecia: thickened basement membrane, ectopic MHC II expression, MAC infiltration into the follicle epithelium, and signs of keratinocyte apoptosis. Loss of distal outer root sheath keratinocytes was detected in 10% of PICC hair follicles (0.2% of all hair follicles). Because PICC were located in the vicinity of the bulge region, MAC-dependent damage to follicle stem cells might eventually lead to follicle degeneration. These perifollicular MAC clusters around selected hair follicles may indicate the existence of a physiological program of MAC dependent controlled follicle degeneration by which damaged or malfunctioning follicles are removed by programmed organ deletion (POD).
KW - Alopecia
KW - Apoptosis
KW - Hair cycle
KW - ICAM 1
KW - Inflammation
KW - Lymphocyte
KW - MHC Class II
KW - Macrophage
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U2 - 10.1177/002215549804600310
DO - 10.1177/002215549804600310
M3 - Article
C2 - 9487118
AN - SCOPUS:0031883889
VL - 46
SP - 361
EP - 370
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
SN - 0022-1554
IS - 3
ER -