Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing

Micaela Giuliana Goldschmidt, Mirta Fabiana Villarreal, Delfina de Achával, Lucas Javier Drucaroff, Elsa Yolanda Costanzo, Mariana Nair Castro, Jaime Pahissa, Joan Camprodon, Charles Nemeroff, Salvador Martín Guinjoan

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Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalPsychiatry Research - Neuroimaging
Issue number1
StatePublished - Jan 30 2014



  • Cluster B
  • FMRI
  • Personality
  • Schizophrenia
  • Siblings
  • Temporo parietal junction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

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