Clopidogrel-induced mixed hepatocellular and cholestatic liver injury

Howard J. Willens

doi:10.1097/00045391-200007050-00009

Clopidogrel-induced mixed hepatocellular and cholestatic liver injury

Howard J. Willens

Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

An 81-year-old woman developed symptomatic liver disease 3 weeks after beginning clopidogrel as adjunctive antiplatelet therapy for a coronary stent implantation. Symptomatic liver disease associated with short-term periprocedural administration of clopidogrel for coronary stenting has not been well described. The clinical significance of this event as well as a possible interaction between clopidogrel and other drugs metabolized by the cytochrome P450 2C9 pathways coadministered to this patient are discussed.

Original language	English (US)
Pages (from-to)	317-318
Number of pages	2
Journal	American journal of therapeutics
Volume	7
Issue number	5
DOIs	https://doi.org/10.1097/00045391-200007050-00009
State	Published - Jan 1 2000

Keywords

Clopidogrel
Drug-induced hepatotoxicity

ASJC Scopus subject areas

Pharmacology

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AB - An 81-year-old woman developed symptomatic liver disease 3 weeks after beginning clopidogrel as adjunctive antiplatelet therapy for a coronary stent implantation. Symptomatic liver disease associated with short-term periprocedural administration of clopidogrel for coronary stenting has not been well described. The clinical significance of this event as well as a possible interaction between clopidogrel and other drugs metabolized by the cytochrome P450 2C9 pathways coadministered to this patient are discussed.

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KW - Drug-induced hepatotoxicity

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Clopidogrel-induced mixed hepatocellular and cholestatic liver injury

Abstract

Keywords

ASJC Scopus subject areas

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