Cloning and characterization of SLP3: A novel member of the stomatin family expressed by olfactory receptor neurons

Bradley J. Goldstein, Heather M. Kulaga, Randall R. Reed

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The detection of odorants with high sensitivity and specificity utilizes specialized transduction proteins that may be assembled into complexes to afford enhanced speed and efficiency in olfactory neurons. We have used a differential cDNA screening technique to identify novel gene products that display restricted expression within the olfactory epithelium. Here we report the characterization of an olfactory neuronal protein, SLP3, which shares extensive homology with the stomatin family of membrane proteins. Other stomatin family members have been implicated in specific interactions with ion channels and G proteincoupled receptors. The pattern of SLP3 mRNA expression during embryonic development and the subcellular localization of the SLP3 protein in mature olfactory neurons observed here is consistent with a specific role for this protein in the assembly, translocation, or function of the odorant transduction complex in olfactory neurons.

Original languageEnglish (US)
Pages (from-to)74-82
Number of pages9
JournalJARO - Journal of the Association for Research in Otolaryngology
Volume4
Issue number1
DOIs
StatePublished - Mar 2003
Externally publishedYes

Keywords

  • Neuron
  • Olfaction
  • Stomatin
  • Transduction

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Physiology

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