Clofazimine enteropathy: A rare and underrecognized complication of mycobacterial therapy

Winnie Szeto; Monica T. Garcia-Buitrago; Lilian Abbo; Joseph D. Rosenblatt; Baharak Moshiree; Michele I. Morris

doi:10.1093/ofid/ofw004

Clofazimine enteropathy: A rare and underrecognized complication of mycobacterial therapy

Winnie Szeto, Monica T. Garcia-Buitrago, Lilian Abbo, Joseph D. Rosenblatt, Baharak Moshiree, Michele I. Morris

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	3
Issue number	3
DOIs	https://doi.org/10.1093/ofid/ofw004
State	Published - May 1 2016

Keywords

Clofazimine
Clofazimine-induced enteropathy
Crystal storing histiocytosis enteropathy
Mycobacterium abscessus
Petechial hemorrhage

ASJC Scopus subject areas

Oncology
Clinical Neurology

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10.1093/ofid/ofw004

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title = "Clofazimine enteropathy: A rare and underrecognized complication of mycobacterial therapy",

abstract = "Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.",

keywords = "Clofazimine, Clofazimine-induced enteropathy, Crystal storing histiocytosis enteropathy, Mycobacterium abscessus, Petechial hemorrhage",

author = "Winnie Szeto and Garcia-Buitrago, {Monica T.} and Lilian Abbo and Rosenblatt, {Joseph D.} and Baharak Moshiree and Morris, {Michele I.}",

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AU - Szeto, Winnie

AU - Garcia-Buitrago, Monica T.

AU - Abbo, Lilian

AU - Rosenblatt, Joseph D.

AU - Moshiree, Baharak

AU - Morris, Michele I.

N1 - Publisher Copyright: © The Author 2016.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.

AB - Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.

KW - Clofazimine

KW - Clofazimine-induced enteropathy

KW - Crystal storing histiocytosis enteropathy

KW - Mycobacterium abscessus

KW - Petechial hemorrhage

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Clofazimine enteropathy: A rare and underrecognized complication of mycobacterial therapy

Abstract

Keywords

ASJC Scopus subject areas

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