Clinicopathologic correlations of retinal membranes associated with intravitreal ‘stem cell’ injections

Rehan M. Hussain, Sander R. Dubovy, Ajay E. Kuriyan, Xiao Yi Zhou, Harry W. Flynn, Thomas A. Albini

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The histologic findings of a subretinal band and epiretinal membrane (ERM) excised from two patients who developed retinal detachments (RDs) after non-U.S. Food and Drug Administration-regulated intravitreal “stem cell” injections are reported. Both membranes were composed of fibrocellular tissue that stained positively with Smooth Muscle Actin and Masson’s trichrome, consistent with collagenous and smooth muscle composition. CD34 immunostain (for hematopoietic cells) was negative for the subretinal band and minimally positive for the ERM. The authors speculate that the “stem cells” may cause RDs by differentiation into myofibroblasts that cause tractional membranes, though further studies are warranted.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number2
StatePublished - Feb 2019

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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