Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis

Gabriela Gualco, Pollyanna Domeny-Duarte, Lucimara Chioato, Glen N Barber, Yasodha Natkunam, Carlos E. Bacchi

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.

Original languageEnglish
Pages (from-to)1195-1203
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number8
DOIs
StatePublished - Aug 1 2011

Fingerprint

Extranodal NK-T-Cell Lymphoma
Human Herpesvirus 4
Nose
Natural Killer T-Cells
T-Cell Lymphoma
Brazil
Central America
Gene Rearrangement
South America
Infection

Keywords

  • angiocentric lymphoma
  • Brazil
  • cytotoxic granules
  • EBV
  • extranasal T/NK
  • nasal type
  • NK/T cell lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis. / Gualco, Gabriela; Domeny-Duarte, Pollyanna; Chioato, Lucimara; Barber, Glen N; Natkunam, Yasodha; Bacchi, Carlos E.

In: American Journal of Surgical Pathology, Vol. 35, No. 8, 01.08.2011, p. 1195-1203.

Research output: Contribution to journalArticle

Gualco, Gabriela ; Domeny-Duarte, Pollyanna ; Chioato, Lucimara ; Barber, Glen N ; Natkunam, Yasodha ; Bacchi, Carlos E. / Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 8. pp. 1195-1203.
@article{da5b3c51ef9f415a8c6c19b3a47b2d7e,
title = "Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis",
abstract = "Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95{\%} and 85{\%} expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89{\%}, and subtype B, 11{\%}. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86{\%}) occurring in the south and southeast regions.",
keywords = "angiocentric lymphoma, Brazil, cytotoxic granules, EBV, extranasal T/NK, nasal type, NK/T cell lymphoma",
author = "Gabriela Gualco and Pollyanna Domeny-Duarte and Lucimara Chioato and Barber, {Glen N} and Yasodha Natkunam and Bacchi, {Carlos E.}",
year = "2011",
month = "8",
day = "1",
doi = "10.1097/PAS.0b013e31821ec4b5",
language = "English",
volume = "35",
pages = "1195--1203",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis

AU - Gualco, Gabriela

AU - Domeny-Duarte, Pollyanna

AU - Chioato, Lucimara

AU - Barber, Glen N

AU - Natkunam, Yasodha

AU - Bacchi, Carlos E.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.

AB - Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.

KW - angiocentric lymphoma

KW - Brazil

KW - cytotoxic granules

KW - EBV

KW - extranasal T/NK

KW - nasal type

KW - NK/T cell lymphoma

UR - http://www.scopus.com/inward/record.url?scp=79961025171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961025171&partnerID=8YFLogxK

U2 - 10.1097/PAS.0b013e31821ec4b5

DO - 10.1097/PAS.0b013e31821ec4b5

M3 - Article

VL - 35

SP - 1195

EP - 1203

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 8

ER -