Abstract
Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.
| Original language | English |
|---|---|
| Pages (from-to) | 1195-1203 |
| Number of pages | 9 |
| Journal | American Journal of Surgical Pathology |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2011 |
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Keywords
- angiocentric lymphoma
- Brazil
- cytotoxic granules
- EBV
- extranasal T/NK
- nasal type
- NK/T cell lymphoma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Surgery
Cite this
Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis. / Gualco, Gabriela; Domeny-Duarte, Pollyanna; Chioato, Lucimara; Barber, Glen N; Natkunam, Yasodha; Bacchi, Carlos E.
In: American Journal of Surgical Pathology, Vol. 35, No. 8, 01.08.2011, p. 1195-1203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis
AU - Gualco, Gabriela
AU - Domeny-Duarte, Pollyanna
AU - Chioato, Lucimara
AU - Barber, Glen N
AU - Natkunam, Yasodha
AU - Bacchi, Carlos E.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.
AB - Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ+ cases showed EBV subtype A. Two TCR-γ+/ CD56+ cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.
KW - angiocentric lymphoma
KW - Brazil
KW - cytotoxic granules
KW - EBV
KW - extranasal T/NK
KW - nasal type
KW - NK/T cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=79961025171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961025171&partnerID=8YFLogxK
U2 - 10.1097/PAS.0b013e31821ec4b5
DO - 10.1097/PAS.0b013e31821ec4b5
M3 - Article
VL - 35
SP - 1195
EP - 1203
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 8
ER -