Abstract
BACKGROUND AND OBJECTIVE: To characterize the range of retinal nerve fiber layer (RNFL) and standard automated perimetry damage in eyes with large vertical cup-disc ratio (VCDR). PATIENTS AND METHODS: Complete examination, standard automated perimetry, scanning laser polarimetry with variable corneal compensation, and optical coherence tomography (OCT) of the RNFL and optic nerve head were performed. Large VCDR was defined as ≥ 0.80 using stereoscopic disc examination and OCT optic nerve head analysis. Structural and functional characteristics were assessed separately in eyes with a disc area of less than 2 mm2, 2 to 2.5 mm2 and greater than 2.5 mm2. RESULTS: Fifty-seven eyes of 57 subjects were enrolled. A broad range in mean deviation (2.0 to -32.8 dB) and mean RNFL thickness with OCT (24.3-100.4 μm) and scanning laser polarimetry with variable corneal compensation (24.0-61.7 μm) was identified. Predictors of standard automated perimetry severity using multiple linear regression were mean RNFL thickness using OCT (P = .001) and scanning laser polarimetry (P = .001), OCT-vertical cup diameter (P = .003), temporal, superior, nasal, inferior, temporal standard deviation (P = .03), and OCT-disc area (P = .04). Eyes with an OCT-disc area of less than 2 mm 2 demonstrated significantly greater standard automated perimetry damage, RNFL loss using OCT and scanning laser polarimetry, and OCT-rim area (P = .002, .0007, .03, and < .0001, respectively) compared with eyes with a disc area of greater than 2.5 mm2. CONCLUSIONS: Eyes with large VCDR have a wide range of RNFL atrophy and standard automated perimetry damage. Small optic discs are associated with more advanced glaucomatous injury.
| Original language | English |
|---|---|
| Pages (from-to) | 401-409 |
| Number of pages | 9 |
| Journal | Ophthalmic Surgery Lasers and Imaging |
| Volume | 36 |
| Issue number | 5 |
| State | Published - Sep 1 2005 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Clinical variables associated with glaucomatous injury in eyes with large optic disc cupping. / Greenfield, David; Bagga, Harmohina.
In: Ophthalmic Surgery Lasers and Imaging, Vol. 36, No. 5, 01.09.2005, p. 401-409.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical variables associated with glaucomatous injury in eyes with large optic disc cupping
AU - Greenfield, David
AU - Bagga, Harmohina
PY - 2005/9/1
Y1 - 2005/9/1
N2 - BACKGROUND AND OBJECTIVE: To characterize the range of retinal nerve fiber layer (RNFL) and standard automated perimetry damage in eyes with large vertical cup-disc ratio (VCDR). PATIENTS AND METHODS: Complete examination, standard automated perimetry, scanning laser polarimetry with variable corneal compensation, and optical coherence tomography (OCT) of the RNFL and optic nerve head were performed. Large VCDR was defined as ≥ 0.80 using stereoscopic disc examination and OCT optic nerve head analysis. Structural and functional characteristics were assessed separately in eyes with a disc area of less than 2 mm2, 2 to 2.5 mm2 and greater than 2.5 mm2. RESULTS: Fifty-seven eyes of 57 subjects were enrolled. A broad range in mean deviation (2.0 to -32.8 dB) and mean RNFL thickness with OCT (24.3-100.4 μm) and scanning laser polarimetry with variable corneal compensation (24.0-61.7 μm) was identified. Predictors of standard automated perimetry severity using multiple linear regression were mean RNFL thickness using OCT (P = .001) and scanning laser polarimetry (P = .001), OCT-vertical cup diameter (P = .003), temporal, superior, nasal, inferior, temporal standard deviation (P = .03), and OCT-disc area (P = .04). Eyes with an OCT-disc area of less than 2 mm 2 demonstrated significantly greater standard automated perimetry damage, RNFL loss using OCT and scanning laser polarimetry, and OCT-rim area (P = .002, .0007, .03, and < .0001, respectively) compared with eyes with a disc area of greater than 2.5 mm2. CONCLUSIONS: Eyes with large VCDR have a wide range of RNFL atrophy and standard automated perimetry damage. Small optic discs are associated with more advanced glaucomatous injury.
AB - BACKGROUND AND OBJECTIVE: To characterize the range of retinal nerve fiber layer (RNFL) and standard automated perimetry damage in eyes with large vertical cup-disc ratio (VCDR). PATIENTS AND METHODS: Complete examination, standard automated perimetry, scanning laser polarimetry with variable corneal compensation, and optical coherence tomography (OCT) of the RNFL and optic nerve head were performed. Large VCDR was defined as ≥ 0.80 using stereoscopic disc examination and OCT optic nerve head analysis. Structural and functional characteristics were assessed separately in eyes with a disc area of less than 2 mm2, 2 to 2.5 mm2 and greater than 2.5 mm2. RESULTS: Fifty-seven eyes of 57 subjects were enrolled. A broad range in mean deviation (2.0 to -32.8 dB) and mean RNFL thickness with OCT (24.3-100.4 μm) and scanning laser polarimetry with variable corneal compensation (24.0-61.7 μm) was identified. Predictors of standard automated perimetry severity using multiple linear regression were mean RNFL thickness using OCT (P = .001) and scanning laser polarimetry (P = .001), OCT-vertical cup diameter (P = .003), temporal, superior, nasal, inferior, temporal standard deviation (P = .03), and OCT-disc area (P = .04). Eyes with an OCT-disc area of less than 2 mm 2 demonstrated significantly greater standard automated perimetry damage, RNFL loss using OCT and scanning laser polarimetry, and OCT-rim area (P = .002, .0007, .03, and < .0001, respectively) compared with eyes with a disc area of greater than 2.5 mm2. CONCLUSIONS: Eyes with large VCDR have a wide range of RNFL atrophy and standard automated perimetry damage. Small optic discs are associated with more advanced glaucomatous injury.
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M3 - Article
C2 - 16238039
AN - SCOPUS:26244465477
VL - 36
SP - 401
EP - 409
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 5
ER -