Clinical value of the creatinine clearance before the administration of chemotherapy with cisplatin

E. Davila, L. B. Gardner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The creatinine clearance was calculated in standard fashion from a timed urine specimen (measured creatinine clearance [MCC]) and from a previously published formula (estimated creatinine clearance [ECC]), in 55 instances, in 19 consecutive patients who were admitted to the hospital for treatment with cisplatin. Using creatinine excretion as an index of completeness of urine collection, there were 19 (35%) inaccurate collections. The correlation between creatinine clearances calculated by both methods was excellent (r = 0.684, P < .001) and improved when inaccurate collections were excluded (r = 0.922, P < 0.001). A discrepancy between the two methods of 25% or more was found in 19 collections. Using data from patients with two or more collections to test whether or not the two methods produced equally variable results, indicated that the MCC is a more variable, less reliable method than the ECC. In eight of 55 urine collections, the results of MCC were not used as a guide to chemotherapy and, in an additional 16 should have not been used because of inaccuracy in the urine collection. These results suggest that the creatinine clearance as calculated by an alternative method (ECC) should replace the use of MCC when assessment of the renal function is needed before the administration of nephrotoxic agents.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalCancer
Volume60
Issue number2
StatePublished - Jan 1 1987
Externally publishedYes

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Cisplatin
Creatinine
Drug Therapy
Urine Specimen Collection
Urine
Kidney

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Clinical value of the creatinine clearance before the administration of chemotherapy with cisplatin. / Davila, E.; Gardner, L. B.

In: Cancer, Vol. 60, No. 2, 01.01.1987, p. 161-164.

Research output: Contribution to journalArticle

Davila, E. ; Gardner, L. B. / Clinical value of the creatinine clearance before the administration of chemotherapy with cisplatin. In: Cancer. 1987 ; Vol. 60, No. 2. pp. 161-164.
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