Interet clinique de l'immunoscintigraphie avec le fragment d'anticorps Fab'-Immu-4 marque au 99mTc avant reintervention chirurgicale dans le cancer du colon ou du rectum

Translated title of the contribution: Clinical utility of immunoscintigraphy with the Immu-4 99mTc-Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum

Jr Moffat, C. M. Pinsky, L. Hammershaimb, N. J. Petrelli, Y. Z. Patt, F. S. Whaley, D. M. Goldenberg

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of these prospective, pivotal studies was to assess the performance and the potential clinical impact of a new antibody imaging agent, CEA-Scan(TM), in 210 presurgical patients with advanced recurrent or metastatic colorectal carcinomas. CEA-Scan(TM), an anti-carcinoembryonic antigen (CEA) Fab' antibody fragment labeled with 99mTc, was injected IV and external scintigraphy performed 2-5 h and 18-24 h later. Imaging with conventional diagnostic modalities (CDM) was also performed, and findings were confirmed by surgery and histology. The sensitivity of CEA-Scan(TM) was superior to that of CDM in the extrahepatic abdomen (55% vs 32%, p = 0,007) and pelvis (69% vs 48%, p = 0,005), and CEA-Scan(TM) findings complemented those of CDM in the liver. Among 122 patients with known disease, the positive predictive value was significantly higher when both modalities were positive (98%) as compared to each alone (68%-70%), potentially obviating the need for histological confirmation when both tests are positive. Imaging accuracy also was significantly improved by adding CEA-Scan(TM) to CDM. In 88 patients with occult cancer, imaging accuracy was enhanced significantly by CEA-Scan(TM) combined with CDM (61% vs 33%). Potential clinical benefit from CEA-Scan(TM) was demonstrated in 89 of 210 patients. Only two patients developed human antimouse antibodies (HAMA) to CEA-Scan(TM) after a single injection, and none of 19 assessable patients after two injections.

Translated title of the contributionClinical utility of immunoscintigraphy with the Immu-4 99mTc-Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum
Original languageFrench
Pages (from-to)275-283
Number of pages9
JournalMedecine Nucleaire
Volume20
Issue number4-5
StatePublished - Jan 1 1996

Keywords

  • Tc-anti-CEA antibody
  • colon-cancer
  • CT-scan
  • immunoscintigraphy
  • surgery

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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