Clinical use of adiponectin as a marker of metabolic dysregulation

Kieren J. Mather, Ronald B. Goldberg

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Adiponectin concentrations exhibit strong cross-sectional relationships with obesity, inflammation, and diabetes. Adiponectin concentrations have been extensively evaluated as epidemiologic markers of diabetes and cardiovascular disease risk. In the present review we will provide an overview of these epidemiologic relationships as the backdrop for an evaluation of the clinical applications of adiponectin measurements. These include using adiponectin as an indicator of need for preventive or therapeutic intervention, as a predictor of response to therapy, and as a marker of therapeutic effectiveness. These efforts are laying the groundwork for the transition of adiponectin measurements from the laboratory to the clinic.

Original languageEnglish (US)
Pages (from-to)107-117
Number of pages11
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • adiponectin
  • inflammation
  • insulin resistance
  • obesity
  • prediction
  • therapy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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