Clinical trials of combination chemotherapy with BCNU and vincristine in the treatment of malignant melanoma in Uganda

Aron Primack, Dhavel Dhru, Jovan W.M. Kiryabwire, Charles L. Vogel

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Sixteen Ugandan patients who had advanced malignant melanoma were treated with a combination of BCNU and vincristine, but only two transient objective tumor responses (13%) were observed. Drug toxicity at the doses used in the present study did not result in clinical complications, and no drug‐related deaths were seen. Leukopenia was observed in all patients but the WBC never fell to less than 1500/mm3. Platelet counts were consistently above 100,000/mm3. The results of therapy with the BCNU‐vincristine combination for advanced malignant melanoma, which have been promising in the United States, have been disappointing in Ugandan patients.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalCancer
Volume31
Issue number2
DOIs
StatePublished - Feb 1973
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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