Clinical trial update on shockwave therapy and future of erectile function restoration

Premal Patel, Chun Huang, Manuel Molina, Ranjith Ramasamy

Research output: Contribution to journalComment/debatepeer-review

4 Scopus citations


Our interim analysis of a phase II clinical trial on low-intensity extracorporeal shockwave therapy (Li-ESWT) for men with erectile dysfunction (ED) has demonstrated it is safe with no reported adverse outcomes. Interim analysis has demonstrated Sexual Encounter Profile 3 (ability to maintain erection till completion) was achieved in 60% of men prior to Li-ESWT, which increased to 90% after treatment. Nevertheless, limitations of our clinical trial include the lack of a sham arm and our inability to exclude men with psychogenic ED. We have begun recruitment of our phase III clinical trial that will allow assessment of treatment efficacy against a sham control arm. There exists substantial interest in the use of restorative therapies (i.e., Li-ESWT, stem cells, and platelet rich plasma) for men with ED with the potential to combine therapies to potentially lead to an augmented response.

Original languageEnglish (US)
Pages (from-to)206-208
Number of pages3
JournalInternational Journal of Impotence Research
Issue number3
StatePublished - May 1 2019

ASJC Scopus subject areas

  • Urology


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