Clinical studies with D-Trp6-luteinizing hormone-releasing hormone in anovulatory women

C. J. Jaramillo, A. Charro-Salgado, V. Peréz-Infante, G. L. del Campo, J. Botella-Llusiá, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


9 anovulatory patients with hypothalamic-pituitary dysfunction were treated with D-Trp6-luteinizing hormone-releasing hormone, an analog with far greater gonadotropin-releasing activity than luteinizing hormone-releasing hormone. 4 of 8 patients, who were formerly unsuccessfully treated with clomiphene, human chorionic gonadotropin, and human menopausal gonadotropin, ovulated after treatment with the peptide alone or with peptide preceded by clomiphene, and 3 became pregnant. The 9th patient, who had amenorrhea and anovulation due to excessive loss of weight caused by anorexia nervosa, also ovulated after treatment with the analog. These results demonstrate the effectiveness of this potent analog for induction of ovulation and pregnancy and point favorably toward clinical applications.

Original languageEnglish (US)
Pages (from-to)418-423
Number of pages6
JournalUnknown Journal
Issue number4
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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