Abstract
PURPOSE: To report 5 cases of fungal keratitis associated with contact lens wear that resolved or significantly improved without antifungal therapy. METHODS: Observational case report of 5 patients with a history of contact lens wear who presented with infectious keratitis. Two patients had growth of fungal species on corneal microbiologic cultures, and of the remaining 3 patients, 2 showed fungal elements on confocal microscopy. All 5 patients exhibited growth of fungal species on contact lens microbiologic cultures. All patients received topical fluoroquinolone therapy as initial treatment. RESULTS: In 3 cases, of whom 2 were treated with moxifloxacin 0.5%, the keratomycosis resolved completely on topical fluoroquinolone therapy. One case was switched to topical tobramycin 14 mg/mL and cefazolin 50 mg/mL with complete resolution of the infection. The final case showed marked initial improvement on fluoroquinolone therapy but was subsequently treated with natamycin 5%. CONCLUSIONS: Fungal keratitis associated with soft contact lens wear may occasionally present in a less aggressive form. Topical fluoroquinolone therapy may be an adjunct to the innate immune response in eradicating less fulminant keratomycosis.
| Original language | English |
|---|---|
| Pages (from-to) | 621-624 |
| Number of pages | 4 |
| Journal | Cornea |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jun 1 2007 |
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Keywords
- Contact lens
- Fluoroquinolone
- Fungus
- Keratitis
- Keratomycosis
ASJC Scopus subject areas
- Ophthalmology
Cite this
Clinical response of contact lens-associated fungal keratitis to topical fluoroquinolone therapy. / Munir, Wuqaas M.; Rosenfeld, Steven I.; Udell, Ira; Miller, Darlene; Karp, Carol; Alfonso, Eduardo C.
In: Cornea, Vol. 26, No. 5, 01.06.2007, p. 621-624.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical response of contact lens-associated fungal keratitis to topical fluoroquinolone therapy
AU - Munir, Wuqaas M.
AU - Rosenfeld, Steven I.
AU - Udell, Ira
AU - Miller, Darlene
AU - Karp, Carol
AU - Alfonso, Eduardo C
PY - 2007/6/1
Y1 - 2007/6/1
N2 - PURPOSE: To report 5 cases of fungal keratitis associated with contact lens wear that resolved or significantly improved without antifungal therapy. METHODS: Observational case report of 5 patients with a history of contact lens wear who presented with infectious keratitis. Two patients had growth of fungal species on corneal microbiologic cultures, and of the remaining 3 patients, 2 showed fungal elements on confocal microscopy. All 5 patients exhibited growth of fungal species on contact lens microbiologic cultures. All patients received topical fluoroquinolone therapy as initial treatment. RESULTS: In 3 cases, of whom 2 were treated with moxifloxacin 0.5%, the keratomycosis resolved completely on topical fluoroquinolone therapy. One case was switched to topical tobramycin 14 mg/mL and cefazolin 50 mg/mL with complete resolution of the infection. The final case showed marked initial improvement on fluoroquinolone therapy but was subsequently treated with natamycin 5%. CONCLUSIONS: Fungal keratitis associated with soft contact lens wear may occasionally present in a less aggressive form. Topical fluoroquinolone therapy may be an adjunct to the innate immune response in eradicating less fulminant keratomycosis.
AB - PURPOSE: To report 5 cases of fungal keratitis associated with contact lens wear that resolved or significantly improved without antifungal therapy. METHODS: Observational case report of 5 patients with a history of contact lens wear who presented with infectious keratitis. Two patients had growth of fungal species on corneal microbiologic cultures, and of the remaining 3 patients, 2 showed fungal elements on confocal microscopy. All 5 patients exhibited growth of fungal species on contact lens microbiologic cultures. All patients received topical fluoroquinolone therapy as initial treatment. RESULTS: In 3 cases, of whom 2 were treated with moxifloxacin 0.5%, the keratomycosis resolved completely on topical fluoroquinolone therapy. One case was switched to topical tobramycin 14 mg/mL and cefazolin 50 mg/mL with complete resolution of the infection. The final case showed marked initial improvement on fluoroquinolone therapy but was subsequently treated with natamycin 5%. CONCLUSIONS: Fungal keratitis associated with soft contact lens wear may occasionally present in a less aggressive form. Topical fluoroquinolone therapy may be an adjunct to the innate immune response in eradicating less fulminant keratomycosis.
KW - Contact lens
KW - Fluoroquinolone
KW - Fungus
KW - Keratitis
KW - Keratomycosis
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UR - http://www.scopus.com/inward/citedby.url?scp=34547463678&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e318033e7e1
DO - 10.1097/ICO.0b013e318033e7e1
M3 - Article
VL - 26
SP - 621
EP - 624
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 5
ER -