Clinical research directions in pediatric cardiology

Steven E Lipshultz, James D. Wilkinson, Sarah Messiah, Tracie L Miller

Research output: Contribution to journalArticle

14 Citations (Scopus)


Purpose of review Clinical research in pediatric cardiology is under-appreciated and under-funded, yet it has enormous implications for cardiovascular health and healthcare over the entire lifecourse. Renewed interest in federally funded clinical research makes it timely to propose a comprehensive research agenda that, with its associated rationale, will attract public funds for research into child cardiovascular health and disease. Recent findings We propose here a comprehensive pediatric cardiology research agenda consisting of 22 topics and associated research questions. We describe the following five topics in more detail: the need for life-course studies of pediatric cardiac disease and epigenetic factors for later onset of cardiovascular effects; the need to study cardiometabolic disease risk in children; recent pediatric cardiology clinical trials and observational studies; the need to explore the role of physical activity in preventing and treating pediatric cardiology patients; and the need to develop and implement evidence-based interventions to manage pediatric cardiovascular problems. Summary If the field of pediatric cardiology can adopt a comprehensive research agenda that identifies the most-needed studies, then research could be better coordinated, longterm and collaborative studies would be more readily organized and funded, and the overall financial and scientific efficiency of research in pediatric cardiology would be improved. Targeted research efforts are more likely to realize potential breakthroughs in areas such as genetic and epigenetic screening, biomarkers, cardioprotective strategies, life-course studies, long-term monitoring technologies, environmental influences on disease, evidence-based practice guidelines, and more rapid and safer development of drugs.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalCurrent Opinion in Pediatrics
Issue number5
StatePublished - Oct 1 2009


Direction compound
Environmental Monitoring
Evidence-Based Practice
Genetic Testing
Financial Management
Practice Guidelines
Observational Studies
Heart Diseases
Cardiovascular Diseases
Clinical Trials
Delivery of Health Care


  • Cardiology
  • Child
  • Clinical trials
  • Epigenetics
  • Late effects
  • Pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical research directions in pediatric cardiology. / Lipshultz, Steven E; Wilkinson, James D.; Messiah, Sarah; Miller, Tracie L.

In: Current Opinion in Pediatrics, Vol. 21, No. 5, 01.10.2009, p. 585-593.

Research output: Contribution to journalArticle

Lipshultz, Steven E ; Wilkinson, James D. ; Messiah, Sarah ; Miller, Tracie L. / Clinical research directions in pediatric cardiology. In: Current Opinion in Pediatrics. 2009 ; Vol. 21, No. 5. pp. 585-593.
title = "Clinical research directions in pediatric cardiology",
abstract = "Lippincott Williams & Wilkins.",
keywords = "Cardiology, Child, Clinical trials, Epigenetics, Late effects, Pediatric",
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