Clinical proton MR spectroscopy in central nervous system disorders

Gülin Öz, Jeffry R. Alger, Peter B. Barker, Robert Bartha, Alberto Bizzi, Chris Boesch, Patrick J. Bolan, Kevin M. Brindle, Cristina Cudalbu, Alp Dinçer, Ulrike Dydak, Uzay E. Emir, Jens Frahm, Ramón Gilberto González, Stephan Gruber, Rolf Gruetter, Rakesh K. Gupta, Arend Heerschap, Anke Henning, Hoby P. HetheringtonFranklyn A. Howe, Petra S. Hüppi, Ralph E. Hurd, Kejal Kantarci, Dennis W.J. Klomp, Roland Kreis, Marijn J. Kruiskamp, Martin O. Leach, Alexander P. Lin, Peter R. Luijten, Małgorzata Marjańska, Andrew A Maudsley, Dieter J. Meyerhoff, Carolyn E. Mountford, Sarah J. Nelson, Necmettin Pamir, Jullie W. Pan, Andrew C. Peet, Harish Poptani, Harish Poptani, Stefan Posse, Petra J.W. Pouwels, Eva Maria Ratai, Brian D. Ross, Tom W.J. Scheenen, Christian Schuster, Ian C.P. Smith, Brian J. Soher, Ivan Tkáč, Daniel B. Vigneron, Risto A. Kauppinen

Research output: Contribution to journalReview article

223 Scopus citations


A large body of published work shows that proton (hydrogen 1 [ 1H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of 1H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of 1H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which 1H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.

Original languageEnglish (US)
Pages (from-to)658-679
Number of pages22
Issue number3
StatePublished - Mar 5 2014
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Öz, G., Alger, J. R., Barker, P. B., Bartha, R., Bizzi, A., Boesch, C., Bolan, P. J., Brindle, K. M., Cudalbu, C., Dinçer, A., Dydak, U., Emir, U. E., Frahm, J., Gilberto González, R., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., ... Kauppinen, R. A. (2014). Clinical proton MR spectroscopy in central nervous system disorders. Radiology, 270(3), 658-679.