The aim of the paper has been to study during a period of six month, of the efficacy and the tolerability of both the lotion and shampoo (Timosint®) containing synthetic low molecular weight thymus peptides (GKL02 Factor), in the initial phases of androgen tic alopecia (AGA), and chronic Telogen Effluvium (TE). Ten women (mean age 31,3 yrs) with AGA (Ludwig 1) and 105 female subjects (mean age 39,96 yrs) with chronic TE have been enrolled; The treatment schedule was as follows: - lotion: twice a day application in the first 15 days and then once a day in the following 22 weeks for a total period of treatment of 24 weeks; - shampoo: two or three times /week during the study period of 24 weeks. All the subjects underwent pull test, evaluation of symptoms (dandruff, seborrhea, redness, pruritus). Tolerability and cosmetic acceptance/tolerance were evaluated at the beginning of the treatment and after 30, 90 and 180 days. In AGA patients the improvement of pull test has been continuous becoming negative in study population after 180gg (p = 0,002). Symptomes decreased in all patients. In chronic TE, pull test become negative in 88% (72 cases out of 82) (p<0,0001) with a mean symptoms' improvement of 88%. In both groups the tolerability was referred as positive in 100% of cases and no side effects were recorded. The cosmetic acceptance/tolerance was also referred as positive in 96% of the cases. In conclusion, synthetic thymus peptides showed significant efficacy and tolerability in the clinical treatment of initial AGA and chronic TE in women after a six month-treatment.
|Number of pages||7|
|Journal||Journal of Plastic Dermatology|
|State||Published - Sep 1 2009|
- Androgenetic alopecia and Telogen Effluvium (TE) in women
- Synthetic thymus peptides
ASJC Scopus subject areas