Abstract
The aim of the paper has been to study during a period of six month, of the efficacy and the tolerability of both the lotion and shampoo (Timosint®) containing synthetic low molecular weight thymus peptides (GKL02 Factor), in the initial phases of androgen tic alopecia (AGA), and chronic Telogen Effluvium (TE). Ten women (mean age 31,3 yrs) with AGA (Ludwig 1) and 105 female subjects (mean age 39,96 yrs) with chronic TE have been enrolled; The treatment schedule was as follows: - lotion: twice a day application in the first 15 days and then once a day in the following 22 weeks for a total period of treatment of 24 weeks; - shampoo: two or three times /week during the study period of 24 weeks. All the subjects underwent pull test, evaluation of symptoms (dandruff, seborrhea, redness, pruritus). Tolerability and cosmetic acceptance/tolerance were evaluated at the beginning of the treatment and after 30, 90 and 180 days. In AGA patients the improvement of pull test has been continuous becoming negative in study population after 180gg (p = 0,002). Symptomes decreased in all patients. In chronic TE, pull test become negative in 88% (72 cases out of 82) (p<0,0001) with a mean symptoms' improvement of 88%. In both groups the tolerability was referred as positive in 100% of cases and no side effects were recorded. The cosmetic acceptance/tolerance was also referred as positive in 96% of the cases. In conclusion, synthetic thymus peptides showed significant efficacy and tolerability in the clinical treatment of initial AGA and chronic TE in women after a six month-treatment.
| Original language | Italian |
|---|---|
| Pages (from-to) | 279-285 |
| Number of pages | 7 |
| Journal | Journal of Plastic Dermatology |
| Volume | 5 |
| Issue number | 3 |
| State | Published - Sep 1 2009 |
| Externally published | Yes |
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Keywords
- Androgenetic alopecia and Telogen Effluvium (TE) in women
- Synthetic thymus peptides
- Therapy
ASJC Scopus subject areas
- Dermatology
Cite this
Studio prospettico a sei mesi sugli effetti di un prodotto topico in lozione e shampoo a base di timo-peptidi di sintesi a basso peso molecolare nel telogen effluvium cronico e nell'AGA iniziale della donna. / Gabrielle, Andreassi Maria; Annalisa, Barba; Daniela, Barbaso; Paola, Bassissi; Cristiana, Belloli; Cristiana, Benedetti Maria; Marina, Bertazzoni; Patrizia, Cannavò; Maria, Cantù Alessandra; Rossana, Capezzera; Giuliana, Caporicci; Anna, Carmagnola; Adriana, Ciuffreda; Giovanna, Cocciò; Maria, Costa Carla; Maria Pia, De Padova; Anna, Di Landro; Elisabetta, Domaneschi; Gabriella, Fabbrocini; Caterina, Ferrara; Piera, Fileccia; Giuseppina, Giuliano; Ezia, Lapucci; Sabrina, Lazzerini; Giuseppina, Mazzola; Maddalena, Montalbano; Romano, Pucci; Corinna, Rigoni; Carmen, Solaroli; Renata, Strumia; Aurora, Tedeschi; Tosti, Antonella; Paola, Vanotti; Cristina, Zane.
In: Journal of Plastic Dermatology, Vol. 5, No. 3, 01.09.2009, p. 279-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Studio prospettico a sei mesi sugli effetti di un prodotto topico in lozione e shampoo a base di timo-peptidi di sintesi a basso peso molecolare nel telogen effluvium cronico e nell'AGA iniziale della donna
AU - Gabrielle, Andreassi Maria
AU - Annalisa, Barba
AU - Daniela, Barbaso
AU - Paola, Bassissi
AU - Cristiana, Belloli
AU - Cristiana, Benedetti Maria
AU - Marina, Bertazzoni
AU - Patrizia, Cannavò
AU - Maria, Cantù Alessandra
AU - Rossana, Capezzera
AU - Giuliana, Caporicci
AU - Anna, Carmagnola
AU - Adriana, Ciuffreda
AU - Giovanna, Cocciò
AU - Maria, Costa Carla
AU - Maria Pia, De Padova
AU - Anna, Di Landro
AU - Elisabetta, Domaneschi
AU - Gabriella, Fabbrocini
AU - Caterina, Ferrara
AU - Piera, Fileccia
AU - Giuseppina, Giuliano
AU - Ezia, Lapucci
AU - Sabrina, Lazzerini
AU - Giuseppina, Mazzola
AU - Maddalena, Montalbano
AU - Romano, Pucci
AU - Corinna, Rigoni
AU - Carmen, Solaroli
AU - Renata, Strumia
AU - Aurora, Tedeschi
AU - Tosti, Antonella
AU - Paola, Vanotti
AU - Cristina, Zane
PY - 2009/9/1
Y1 - 2009/9/1
N2 - The aim of the paper has been to study during a period of six month, of the efficacy and the tolerability of both the lotion and shampoo (Timosint®) containing synthetic low molecular weight thymus peptides (GKL02 Factor), in the initial phases of androgen tic alopecia (AGA), and chronic Telogen Effluvium (TE). Ten women (mean age 31,3 yrs) with AGA (Ludwig 1) and 105 female subjects (mean age 39,96 yrs) with chronic TE have been enrolled; The treatment schedule was as follows: - lotion: twice a day application in the first 15 days and then once a day in the following 22 weeks for a total period of treatment of 24 weeks; - shampoo: two or three times /week during the study period of 24 weeks. All the subjects underwent pull test, evaluation of symptoms (dandruff, seborrhea, redness, pruritus). Tolerability and cosmetic acceptance/tolerance were evaluated at the beginning of the treatment and after 30, 90 and 180 days. In AGA patients the improvement of pull test has been continuous becoming negative in study population after 180gg (p = 0,002). Symptomes decreased in all patients. In chronic TE, pull test become negative in 88% (72 cases out of 82) (p<0,0001) with a mean symptoms' improvement of 88%. In both groups the tolerability was referred as positive in 100% of cases and no side effects were recorded. The cosmetic acceptance/tolerance was also referred as positive in 96% of the cases. In conclusion, synthetic thymus peptides showed significant efficacy and tolerability in the clinical treatment of initial AGA and chronic TE in women after a six month-treatment.
AB - The aim of the paper has been to study during a period of six month, of the efficacy and the tolerability of both the lotion and shampoo (Timosint®) containing synthetic low molecular weight thymus peptides (GKL02 Factor), in the initial phases of androgen tic alopecia (AGA), and chronic Telogen Effluvium (TE). Ten women (mean age 31,3 yrs) with AGA (Ludwig 1) and 105 female subjects (mean age 39,96 yrs) with chronic TE have been enrolled; The treatment schedule was as follows: - lotion: twice a day application in the first 15 days and then once a day in the following 22 weeks for a total period of treatment of 24 weeks; - shampoo: two or three times /week during the study period of 24 weeks. All the subjects underwent pull test, evaluation of symptoms (dandruff, seborrhea, redness, pruritus). Tolerability and cosmetic acceptance/tolerance were evaluated at the beginning of the treatment and after 30, 90 and 180 days. In AGA patients the improvement of pull test has been continuous becoming negative in study population after 180gg (p = 0,002). Symptomes decreased in all patients. In chronic TE, pull test become negative in 88% (72 cases out of 82) (p<0,0001) with a mean symptoms' improvement of 88%. In both groups the tolerability was referred as positive in 100% of cases and no side effects were recorded. The cosmetic acceptance/tolerance was also referred as positive in 96% of the cases. In conclusion, synthetic thymus peptides showed significant efficacy and tolerability in the clinical treatment of initial AGA and chronic TE in women after a six month-treatment.
KW - Androgenetic alopecia and Telogen Effluvium (TE) in women
KW - Synthetic thymus peptides
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=77649112258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77649112258&partnerID=8YFLogxK
M3 - Article
VL - 5
SP - 279
EP - 285
JO - Journal of Plastic Dermatology
JF - Journal of Plastic Dermatology
SN - 2035-0686
IS - 3
ER -