Studio prospettico a sei mesi sugli effetti di un prodotto topico in lozione e shampoo a base di timo-peptidi di sintesi a basso peso molecolare nel telogen effluvium cronico e nell'AGA iniziale della donna

Translated title of the contribution: Clinical investigation of the effects of topical lotion and shampoo containing synthetic thymus peptides on androgenetic alopecia and chronic telogen effluvium in women after a six month-period treatment

Andreassi Maria Gabrielle, Barba Annalisa, Barbaso Daniela, Bassissi Paola, Belloli Cristiana, Benedetti Maria Cristiana, Bertazzoni Marina, Cannavò Patrizia, Cantù Alessandra Maria, Capezzera Rossana, Caporicci Giuliana, Carmagnola Anna, Ciuffreda Adriana, Cocciò Giovanna, Costa Carla Maria, De Padova Maria Pia, Di Landro Anna, Domaneschi Elisabetta, Fabbrocini Gabriella, Ferrara CaterinaFileccia Piera, Giuliano Giuseppina, Lapucci Ezia, Lazzerini Sabrina, Mazzola Giuseppina, Montalbano Maddalena, Pucci Romano, Rigoni Corinna, Solaroli Carmen, Strumia Renata, Tedeschi Aurora, Tosti Antonella, Vanotti Paola, Zane Cristina

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The aim of the paper has been to study during a period of six month, of the efficacy and the tolerability of both the lotion and shampoo (Timosint®) containing synthetic low molecular weight thymus peptides (GKL02 Factor), in the initial phases of androgen tic alopecia (AGA), and chronic Telogen Effluvium (TE). Ten women (mean age 31,3 yrs) with AGA (Ludwig 1) and 105 female subjects (mean age 39,96 yrs) with chronic TE have been enrolled; The treatment schedule was as follows: - lotion: twice a day application in the first 15 days and then once a day in the following 22 weeks for a total period of treatment of 24 weeks; - shampoo: two or three times /week during the study period of 24 weeks. All the subjects underwent pull test, evaluation of symptoms (dandruff, seborrhea, redness, pruritus). Tolerability and cosmetic acceptance/tolerance were evaluated at the beginning of the treatment and after 30, 90 and 180 days. In AGA patients the improvement of pull test has been continuous becoming negative in study population after 180gg (p = 0,002). Symptomes decreased in all patients. In chronic TE, pull test become negative in 88% (72 cases out of 82) (p<0,0001) with a mean symptoms' improvement of 88%. In both groups the tolerability was referred as positive in 100% of cases and no side effects were recorded. The cosmetic acceptance/tolerance was also referred as positive in 96% of the cases. In conclusion, synthetic thymus peptides showed significant efficacy and tolerability in the clinical treatment of initial AGA and chronic TE in women after a six month-treatment.

Original languageItalian
Pages (from-to)279-285
Number of pages7
JournalJournal of Plastic Dermatology
Volume5
Issue number3
StatePublished - Sep 1 2009
Externally publishedYes

    Fingerprint

Keywords

  • Androgenetic alopecia and Telogen Effluvium (TE) in women
  • Synthetic thymus peptides
  • Therapy

ASJC Scopus subject areas

  • Dermatology

Cite this

Gabrielle, A. M., Annalisa, B., Daniela, B., Paola, B., Cristiana, B., Cristiana, B. M., Marina, B., Patrizia, C., Maria, C. A., Rossana, C., Giuliana, C., Anna, C., Adriana, C., Giovanna, C., Maria, C. C., Maria Pia, D. P., Anna, D. L., Elisabetta, D., Gabriella, F., ... Cristina, Z. (2009). Studio prospettico a sei mesi sugli effetti di un prodotto topico in lozione e shampoo a base di timo-peptidi di sintesi a basso peso molecolare nel telogen effluvium cronico e nell'AGA iniziale della donna. Journal of Plastic Dermatology, 5(3), 279-285.