Clinical implications of glucocorticoid receptors in human leukemia

Marc E Lippman, G. Konior Yarbro, B. G. Leventhal

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Glucocorticoid receptors were studied in various populations of normal human peripheral blood lymphocytes and leukemic lymphoblasts. Normal lymphocytes contain low levels of glucocorticoid receptor (~2,500 sites/cell) which are identical in T- and non-T-fractions. Phytohemagglutinin treatment increases levels about 3-fold. Leukemic lymphoblasts contain larger numbers of receptor sites. Presence of receptor is correlated with in vitro sensitivity to glucocorticoids and in vivo response to therapy. Quantity of receptor is also correlated with complete remission duration independently of leukemic cell type (T or null), initial WBC, or age of patient. Quantitative determination of glucocorticoid receptor levels in acute lymphoblastic leukemia may be of value both as an independent prognostic variable and in suggesting which patients should receive glucocorticoid therapy.

Original languageEnglish
Pages (from-to)4251-4256
Number of pages6
JournalCancer Research
Volume38
Issue number11 II
StatePublished - Dec 1 1978
Externally publishedYes

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Glucocorticoid Receptors
Leukemia
Glucocorticoids
Lymphocytes
Phytohemagglutinins
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutics
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lippman, M. E., Konior Yarbro, G., & Leventhal, B. G. (1978). Clinical implications of glucocorticoid receptors in human leukemia. Cancer Research, 38(11 II), 4251-4256.

Clinical implications of glucocorticoid receptors in human leukemia. / Lippman, Marc E; Konior Yarbro, G.; Leventhal, B. G.

In: Cancer Research, Vol. 38, No. 11 II, 01.12.1978, p. 4251-4256.

Research output: Contribution to journalArticle

Lippman, ME, Konior Yarbro, G & Leventhal, BG 1978, 'Clinical implications of glucocorticoid receptors in human leukemia', Cancer Research, vol. 38, no. 11 II, pp. 4251-4256.
Lippman ME, Konior Yarbro G, Leventhal BG. Clinical implications of glucocorticoid receptors in human leukemia. Cancer Research. 1978 Dec 1;38(11 II):4251-4256.
Lippman, Marc E ; Konior Yarbro, G. ; Leventhal, B. G. / Clinical implications of glucocorticoid receptors in human leukemia. In: Cancer Research. 1978 ; Vol. 38, No. 11 II. pp. 4251-4256.
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