Clinical Implications of Glucocorticoid Receptors in Human Leukemia

Marc E. Lippman

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Glucocorticoid receptors were studied in various populations of normal human peripheral blood lymphocytes and leukemic lymphoblasts. Normal lymphocytes contain low levels of glucocorticoid receptor (~2,500 sites/cell) which are identical in T- and non-T-fractions. Phytohemagglutinin treatment increases levels about 3-fold. Leukemic lymphoblasts contain larger numbers of receptor sites. Presence of receptor is correlated with in vitro sensitivity to glucocorticoids and in vivo response to therapy. Quantity of receptor is also correlated with complete remission duration independently of leukemic cell type (T or null), initial WBC, or age of patient. Quantitative determination of glucocorticoid receptor levels in acute lymphoblastic leukemia may be of value both as an independent prognostic variable and in suggesting which patients should receive glucocorticoid therapy.

Original languageEnglish (US)
Pages (from-to)4251-4256
Number of pages6
JournalCancer Research
Volume38
StatePublished - Nov 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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