Abstract
Normal lymphoid cells contain glucocorticoid receptor. A variety of stimuli that activate these cells also induce increases in receptor concentration. Similar glucocorticoid receptors can be detected in lymphoid cells from patients with acute lymphoblastic leukemia (ALL). Absence of the glucocorticoid receptor (usually found in treated patients) predicts lack of glucocorticoid responsiveness. Furthermore, in our hands, glucocorticoid receptor levels correlate with the duration of complete remission in ALL (though not in other forms of leukemia). This association is independent of cell type, age, sex, or initial leukocyte count. The level of receptor shows a negative correlation with increasing aggressiveness of the tumor (null-cell leukemia greater than T-cell leukemia greater than Burkitt's lymphoma).
| Original language | English |
|---|---|
| Journal | The American journal of physiology |
| Volume | 243 |
| Issue number | 2 |
| State | Published - Aug 1 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Clinical implications of glucocorticoid receptors in human leukemia. / Lippman, Marc E.
In: The American journal of physiology, Vol. 243, No. 2, 01.08.1982.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical implications of glucocorticoid receptors in human leukemia.
AU - Lippman, Marc E
PY - 1982/8/1
Y1 - 1982/8/1
N2 - Normal lymphoid cells contain glucocorticoid receptor. A variety of stimuli that activate these cells also induce increases in receptor concentration. Similar glucocorticoid receptors can be detected in lymphoid cells from patients with acute lymphoblastic leukemia (ALL). Absence of the glucocorticoid receptor (usually found in treated patients) predicts lack of glucocorticoid responsiveness. Furthermore, in our hands, glucocorticoid receptor levels correlate with the duration of complete remission in ALL (though not in other forms of leukemia). This association is independent of cell type, age, sex, or initial leukocyte count. The level of receptor shows a negative correlation with increasing aggressiveness of the tumor (null-cell leukemia greater than T-cell leukemia greater than Burkitt's lymphoma).
AB - Normal lymphoid cells contain glucocorticoid receptor. A variety of stimuli that activate these cells also induce increases in receptor concentration. Similar glucocorticoid receptors can be detected in lymphoid cells from patients with acute lymphoblastic leukemia (ALL). Absence of the glucocorticoid receptor (usually found in treated patients) predicts lack of glucocorticoid responsiveness. Furthermore, in our hands, glucocorticoid receptor levels correlate with the duration of complete remission in ALL (though not in other forms of leukemia). This association is independent of cell type, age, sex, or initial leukocyte count. The level of receptor shows a negative correlation with increasing aggressiveness of the tumor (null-cell leukemia greater than T-cell leukemia greater than Burkitt's lymphoma).
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UR - http://www.scopus.com/inward/citedby.url?scp=0020170559&partnerID=8YFLogxK
M3 - Article
C2 - 6956240
AN - SCOPUS:0020170559
VL - 243
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 2
ER -