Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease: Clinical article

Robert M. Starke, Ricardo J Komotar, Zachary L. Hickman, Yehuda E. Paz, Angela G. Pugliese, Marc L. Otten, Matthew C. Garrett, Mitchell S V Elkind, Randolph S. Marshall, Joanne R. Festa, Philip M. Meyers, E. Sander Connolly

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Object. The object of this study was to report the clinical features, surgical treatment, and long-term outcomes in adults with moyamoya phenomenon treated at a single institution in the US. Methods. Forty-three adult patients with moyamoya disease (mean age 40 ± 11 years [SD], range 18-69 years) were treated with encephaloduroarteriosynangiosis (EDAS). Neurologists examined patients pre- and postoperatively. Follow-up was obtained in person or by structured telephone interview (median 41 months, range 4-126 months). The following outcomes were collected: transient ischemic attack (TIA), infarction, graft collateralization, change in cerebral perfusion, and functional level according to the modified Rankin scale (mRS). Kaplan-Meier estimates of infarction risk were calculated for comparison of surgically treated and contralateral hemispheres. Results. The majority of patients were women (65%), were Caucasian (65%), presented with ischemic symptoms (98%), and had bilateral disease (86%). Nineteen patients underwent unilateral and 24 patients bilateral EDAS (67 treated hemispheres). Collateral vessels developed in 50 (98%) of 52 hemispheres for which imaging was available and there was evidence of increased perfusion on SPECT scans in 41 (82%) of the 50 hemispheres evaluated. Periprocedural infarction (< 48 hours) occurred in 3% of the hemispheres treated. In the follow-up period patients experienced 10 TIAs, 6 infarctions, and 1 intracranial hemorrhage. Although the hemisphere selected for surgery was based upon patients' symptoms and severity of pathology, the 5-year infarction-free survival rate was 94% in the surgically treated hemispheres versus < 36% in the untreated hemispheres (p = 0.007). After controlling for age and sex, infarction was 89% less likely to occur in the surgically treated hemispheres than in the contralateral hemispheres (hazard ratio 0.11, 95% CI 0.02-0.56). Thirty-eight (88%) of 43 patients had preserved or improved mRS scores, relative to baseline status. Conclusions. In this mixed-race population of North American patients, indirect bypass promoted adequate pial collateral development and increased perfusion in the majority of adult patients with moyamoya disease. Patients had low rates of postoperative TIAs, infarction, and hemorrhage, and the majority of patients had preserved or improved functional status.

Original languageEnglish
Pages (from-to)936-942
Number of pages7
JournalJournal of Neurosurgery
Volume111
Issue number5
DOIs
StatePublished - Dec 8 2009
Externally publishedYes

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Moyamoya Disease
Infarction
Therapeutics
Perfusion
Intracranial Hemorrhages
Transient Ischemic Attack
Kaplan-Meier Estimate
Single-Photon Emission-Computed Tomography

Keywords

  • Encephaloduroarteriosynangiosis
  • Indirect bypass
  • Moyamoya disease
  • Outcome
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease : Clinical article. / Starke, Robert M.; Komotar, Ricardo J; Hickman, Zachary L.; Paz, Yehuda E.; Pugliese, Angela G.; Otten, Marc L.; Garrett, Matthew C.; Elkind, Mitchell S V; Marshall, Randolph S.; Festa, Joanne R.; Meyers, Philip M.; Connolly, E. Sander.

In: Journal of Neurosurgery, Vol. 111, No. 5, 08.12.2009, p. 936-942.

Research output: Contribution to journalArticle

Starke, RM, Komotar, RJ, Hickman, ZL, Paz, YE, Pugliese, AG, Otten, ML, Garrett, MC, Elkind, MSV, Marshall, RS, Festa, JR, Meyers, PM & Connolly, ES 2009, 'Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease: Clinical article', Journal of Neurosurgery, vol. 111, no. 5, pp. 936-942. https://doi.org/10.3171/2009.3.JNS08837
Starke, Robert M. ; Komotar, Ricardo J ; Hickman, Zachary L. ; Paz, Yehuda E. ; Pugliese, Angela G. ; Otten, Marc L. ; Garrett, Matthew C. ; Elkind, Mitchell S V ; Marshall, Randolph S. ; Festa, Joanne R. ; Meyers, Philip M. ; Connolly, E. Sander. / Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease : Clinical article. In: Journal of Neurosurgery. 2009 ; Vol. 111, No. 5. pp. 936-942.
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AU - Hickman, Zachary L.

AU - Paz, Yehuda E.

AU - Pugliese, Angela G.

AU - Otten, Marc L.

AU - Garrett, Matthew C.

AU - Elkind, Mitchell S V

AU - Marshall, Randolph S.

AU - Festa, Joanne R.

AU - Meyers, Philip M.

AU - Connolly, E. Sander

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Y1 - 2009/12/8

N2 - Object. The object of this study was to report the clinical features, surgical treatment, and long-term outcomes in adults with moyamoya phenomenon treated at a single institution in the US. Methods. Forty-three adult patients with moyamoya disease (mean age 40 ± 11 years [SD], range 18-69 years) were treated with encephaloduroarteriosynangiosis (EDAS). Neurologists examined patients pre- and postoperatively. Follow-up was obtained in person or by structured telephone interview (median 41 months, range 4-126 months). The following outcomes were collected: transient ischemic attack (TIA), infarction, graft collateralization, change in cerebral perfusion, and functional level according to the modified Rankin scale (mRS). Kaplan-Meier estimates of infarction risk were calculated for comparison of surgically treated and contralateral hemispheres. Results. The majority of patients were women (65%), were Caucasian (65%), presented with ischemic symptoms (98%), and had bilateral disease (86%). Nineteen patients underwent unilateral and 24 patients bilateral EDAS (67 treated hemispheres). Collateral vessels developed in 50 (98%) of 52 hemispheres for which imaging was available and there was evidence of increased perfusion on SPECT scans in 41 (82%) of the 50 hemispheres evaluated. Periprocedural infarction (< 48 hours) occurred in 3% of the hemispheres treated. In the follow-up period patients experienced 10 TIAs, 6 infarctions, and 1 intracranial hemorrhage. Although the hemisphere selected for surgery was based upon patients' symptoms and severity of pathology, the 5-year infarction-free survival rate was 94% in the surgically treated hemispheres versus < 36% in the untreated hemispheres (p = 0.007). After controlling for age and sex, infarction was 89% less likely to occur in the surgically treated hemispheres than in the contralateral hemispheres (hazard ratio 0.11, 95% CI 0.02-0.56). Thirty-eight (88%) of 43 patients had preserved or improved mRS scores, relative to baseline status. Conclusions. In this mixed-race population of North American patients, indirect bypass promoted adequate pial collateral development and increased perfusion in the majority of adult patients with moyamoya disease. Patients had low rates of postoperative TIAs, infarction, and hemorrhage, and the majority of patients had preserved or improved functional status.

AB - Object. The object of this study was to report the clinical features, surgical treatment, and long-term outcomes in adults with moyamoya phenomenon treated at a single institution in the US. Methods. Forty-three adult patients with moyamoya disease (mean age 40 ± 11 years [SD], range 18-69 years) were treated with encephaloduroarteriosynangiosis (EDAS). Neurologists examined patients pre- and postoperatively. Follow-up was obtained in person or by structured telephone interview (median 41 months, range 4-126 months). The following outcomes were collected: transient ischemic attack (TIA), infarction, graft collateralization, change in cerebral perfusion, and functional level according to the modified Rankin scale (mRS). Kaplan-Meier estimates of infarction risk were calculated for comparison of surgically treated and contralateral hemispheres. Results. The majority of patients were women (65%), were Caucasian (65%), presented with ischemic symptoms (98%), and had bilateral disease (86%). Nineteen patients underwent unilateral and 24 patients bilateral EDAS (67 treated hemispheres). Collateral vessels developed in 50 (98%) of 52 hemispheres for which imaging was available and there was evidence of increased perfusion on SPECT scans in 41 (82%) of the 50 hemispheres evaluated. Periprocedural infarction (< 48 hours) occurred in 3% of the hemispheres treated. In the follow-up period patients experienced 10 TIAs, 6 infarctions, and 1 intracranial hemorrhage. Although the hemisphere selected for surgery was based upon patients' symptoms and severity of pathology, the 5-year infarction-free survival rate was 94% in the surgically treated hemispheres versus < 36% in the untreated hemispheres (p = 0.007). After controlling for age and sex, infarction was 89% less likely to occur in the surgically treated hemispheres than in the contralateral hemispheres (hazard ratio 0.11, 95% CI 0.02-0.56). Thirty-eight (88%) of 43 patients had preserved or improved mRS scores, relative to baseline status. Conclusions. In this mixed-race population of North American patients, indirect bypass promoted adequate pial collateral development and increased perfusion in the majority of adult patients with moyamoya disease. Patients had low rates of postoperative TIAs, infarction, and hemorrhage, and the majority of patients had preserved or improved functional status.

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KW - Moyamoya disease

KW - Outcome

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