Clinical features and management of subretinal abscesses secondary to methicillinresistant staphylococcus aureus endogenous endophthalmitis

Jorge Fortun, Yasha S. Modi, Angela Bessette, Jordan Heffez, Petros Carvounis, Daniel S. Petkovsek, Nicholas G. Anderson, Daniel Martin, Sunil Srivastava

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Abstract

BACKGROUND AND OBJECTIVE: To describe the clinical features, management, and immediate outcomes of patients with subretinal abscesses secondary to methicillin-resistant Staphylococcus aureus (MRSA) endogenous endophthalmitis. PATIENTS AND METHODS: Eleven eyes of seven patients were identifed by retrospective chart review. Demographics, initial presentation, examination fndings, imaging, cultures, treatments, and shortterm outcomes were reviewed. RESULTS: Eleven eyes of seven patients presented with subretinal abscesses secondary to MRSA endogenous endophthalmitis. Four had history of recurrent MRSA infections or active soft-tissue ulceration. Six underwent vitreous tap for culture without growth. Three had positive blood cultures for MRSA. Six received empiric therapy with intravenous vancomycin, one received oral trimethoprim-sulfamethoxazole, and six received intravitreal vancomycin. Consolidation of abscesses was seen within days of initial treatment. Visual outcomes were contingent on abscess location and time to initial treatment. CONCLUSION: Prompt diagnosis and systemic antibiotic therapy is paramount in the treatment of this rare presentation.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume48
Issue number2
DOIs
StatePublished - Feb 1 2017

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ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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