Clinical evidence for hepatitis B transmission resulting from corneal transplantation

Richard H. Hoft, Stephen C. Pflugfelder, Richard Forster, Saul Ullman, Frank M. Polack, Eugene R Schiff

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Purpose. Two cases of hepatitis B virus (HBV) infection after penetrating keratoplasty are presented. Methods. An extensive clinical and serologic investigation of these two transplant recipients was performed. In addition, the medical histories, autopsy reports, and specimens of blood from the two deceased corneal tissue donors were retrieved and studied. Results. Serum from both donors was positive for hepatitis B surface antigen; the clinical history and serologic testing of both recipients strongly suggest that the HBV infection in each case was acquired from donor corneal tissue. Conclusion. To our knowledge, these are the first documented cases of HBV infection after corneal transplantation. Eye banks should continue to screen donors for HBV.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalCornea
Volume16
Issue number2
StatePublished - Mar 1 1997

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Corneal Transplantation
Hepatitis B
Hepatitis B virus
Virus Diseases
Tissue Donors
Eye Banks
Penetrating Keratoplasty
Hepatitis B Surface Antigens
Autopsy
Serum

Keywords

  • Corneal transplantation
  • Donor corneal tissue
  • Eye banking
  • Hepatitis B transmission
  • Hepatitis B virus (HBV) infection
  • Keratoplasty
  • Tissue transplantation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Hoft, R. H., Pflugfelder, S. C., Forster, R., Ullman, S., Polack, F. M., & Schiff, E. R. (1997). Clinical evidence for hepatitis B transmission resulting from corneal transplantation. Cornea, 16(2), 132-137.

Clinical evidence for hepatitis B transmission resulting from corneal transplantation. / Hoft, Richard H.; Pflugfelder, Stephen C.; Forster, Richard; Ullman, Saul; Polack, Frank M.; Schiff, Eugene R.

In: Cornea, Vol. 16, No. 2, 01.03.1997, p. 132-137.

Research output: Contribution to journalArticle

Hoft, RH, Pflugfelder, SC, Forster, R, Ullman, S, Polack, FM & Schiff, ER 1997, 'Clinical evidence for hepatitis B transmission resulting from corneal transplantation', Cornea, vol. 16, no. 2, pp. 132-137.
Hoft RH, Pflugfelder SC, Forster R, Ullman S, Polack FM, Schiff ER. Clinical evidence for hepatitis B transmission resulting from corneal transplantation. Cornea. 1997 Mar 1;16(2):132-137.
Hoft, Richard H. ; Pflugfelder, Stephen C. ; Forster, Richard ; Ullman, Saul ; Polack, Frank M. ; Schiff, Eugene R. / Clinical evidence for hepatitis B transmission resulting from corneal transplantation. In: Cornea. 1997 ; Vol. 16, No. 2. pp. 132-137.
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