Clinical evaluation of a scintigraphic method for diagnosing inflammations/infections using indium-111-labeled nonspecific human IgG

A. N. Serafini, I. Garty, R. Vargas-Cuba, A. Friedman, D. A. Rauh, M. Neptune, L. Landress, G. N. Sfakianakis

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Abstract

This study was undertaken as part of a Phase II study to assess the sensitivity and safety of 111In-DTPA-human IgG, an imaging agent for the detection of inflammations and/or infections. Forty patients with infection/inflammation on the basis of clinical findings, microbiologic results, and/or the basis of results from other imaging modalities were studied. For evaluation of sensitivity, whole-body images were obtained at 6- 12 hr (early) and 20-28 hr (delayed) postinjection and occasionally at 48 hr. No adverse reactions were recorded in any of the 40 patients studied. Positive results were obtained in 37 of 37 evaluable subjects (100%). The test appears to be a promising method for the detection of inflammation and/or infection.

Original languageEnglish (US)
Pages (from-to)2227-2232
Number of pages6
JournalJournal of Nuclear Medicine
Volume32
Issue number12
StatePublished - Dec 1 1991

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Serafini, A. N., Garty, I., Vargas-Cuba, R., Friedman, A., Rauh, D. A., Neptune, M., Landress, L., & Sfakianakis, G. N. (1991). Clinical evaluation of a scintigraphic method for diagnosing inflammations/infections using indium-111-labeled nonspecific human IgG. Journal of Nuclear Medicine, 32(12), 2227-2232.