Abstract
Objectives: To evaluate feasibility and accuracy of a fully automatic algorithm (FAA) for calculating left ventricular volumes and ejection fraction (LVEF) from multidetector computed tomography (MDCT) studies versus a previously validated method based on Simpson's method serving as our reference standard (RS), and left ventriculography (LVG), in patients with acute chest pain (ACP). Methods: 23 patients admitted with ACP underwent ECG-gated MDCT, as well as LVG during their hospitalization. MDCT based end-diastolic, end-systolic and stroke volumes (EDV, ESV, SV) and LVEF were calculated using the RS and the FAA. Results: One patient was excluded after FAA failure to detect contours. In the remaining 22 patients, meanSD LVEF measurements were RS 6111%, FAA 5911% (r = 0.91 versus RS), LVG 5716% (r = 0.6 versus RS). In comparison to RS, FAA overestimated EDV by 10.18.5 ml, ESV by 7.36.4 ml and SV by 3.68.6 ml, and underestimated LVEF measurements by 2.74.6%, related to contour smoothing. LVEF by FAA was within 8% of RS for all patients except one. In contrast, LVG differed significantly from RS. Conclusions: The evaluated FAA obtained accurate, clinically relevant results for left ventricular volumes and LVEF relative to the RS.
| Original language | English |
|---|---|
| Pages (from-to) | 43-51 |
| Number of pages | 9 |
| Journal | Acute Cardiac Care |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1 2009 |
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Keywords
- Acute coronary syndrome
- Cardiac volume
- Computed tomography
- Imaging
- Left ventricular function
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
- Emergency Medicine
Cite this
Clinical evaluation of a fully automated model-based algorithm to calculate left ventricular volumes and ejection fraction using multidetector computed tomography. / Ghersin, Eduard; Abadi, Sobhi; Yalonetsky, Sergey; Engel, Ahuva; Lessick, Jonathan.
In: Acute Cardiac Care, Vol. 11, No. 1, 01.04.2009, p. 43-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical evaluation of a fully automated model-based algorithm to calculate left ventricular volumes and ejection fraction using multidetector computed tomography
AU - Ghersin, Eduard
AU - Abadi, Sobhi
AU - Yalonetsky, Sergey
AU - Engel, Ahuva
AU - Lessick, Jonathan
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Objectives: To evaluate feasibility and accuracy of a fully automatic algorithm (FAA) for calculating left ventricular volumes and ejection fraction (LVEF) from multidetector computed tomography (MDCT) studies versus a previously validated method based on Simpson's method serving as our reference standard (RS), and left ventriculography (LVG), in patients with acute chest pain (ACP). Methods: 23 patients admitted with ACP underwent ECG-gated MDCT, as well as LVG during their hospitalization. MDCT based end-diastolic, end-systolic and stroke volumes (EDV, ESV, SV) and LVEF were calculated using the RS and the FAA. Results: One patient was excluded after FAA failure to detect contours. In the remaining 22 patients, meanSD LVEF measurements were RS 6111%, FAA 5911% (r = 0.91 versus RS), LVG 5716% (r = 0.6 versus RS). In comparison to RS, FAA overestimated EDV by 10.18.5 ml, ESV by 7.36.4 ml and SV by 3.68.6 ml, and underestimated LVEF measurements by 2.74.6%, related to contour smoothing. LVEF by FAA was within 8% of RS for all patients except one. In contrast, LVG differed significantly from RS. Conclusions: The evaluated FAA obtained accurate, clinically relevant results for left ventricular volumes and LVEF relative to the RS.
AB - Objectives: To evaluate feasibility and accuracy of a fully automatic algorithm (FAA) for calculating left ventricular volumes and ejection fraction (LVEF) from multidetector computed tomography (MDCT) studies versus a previously validated method based on Simpson's method serving as our reference standard (RS), and left ventriculography (LVG), in patients with acute chest pain (ACP). Methods: 23 patients admitted with ACP underwent ECG-gated MDCT, as well as LVG during their hospitalization. MDCT based end-diastolic, end-systolic and stroke volumes (EDV, ESV, SV) and LVEF were calculated using the RS and the FAA. Results: One patient was excluded after FAA failure to detect contours. In the remaining 22 patients, meanSD LVEF measurements were RS 6111%, FAA 5911% (r = 0.91 versus RS), LVG 5716% (r = 0.6 versus RS). In comparison to RS, FAA overestimated EDV by 10.18.5 ml, ESV by 7.36.4 ml and SV by 3.68.6 ml, and underestimated LVEF measurements by 2.74.6%, related to contour smoothing. LVEF by FAA was within 8% of RS for all patients except one. In contrast, LVG differed significantly from RS. Conclusions: The evaluated FAA obtained accurate, clinically relevant results for left ventricular volumes and LVEF relative to the RS.
KW - Acute coronary syndrome
KW - Cardiac volume
KW - Computed tomography
KW - Imaging
KW - Left ventricular function
UR - http://www.scopus.com/inward/record.url?scp=67049109140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67049109140&partnerID=8YFLogxK
U2 - 10.1080/17482940802588317
DO - 10.1080/17482940802588317
M3 - Article
C2 - 19396643
AN - SCOPUS:67049109140
VL - 11
SP - 43
EP - 51
JO - Acute Cardiac Care
JF - Acute Cardiac Care
SN - 1748-2941
IS - 1
ER -