Clinical Correlations of Steroid Receptors and Male Breast Cancer 1

Richard B. Everson, Marc E. Lippman, E. Brad Thompson, William L. McGuire, James L. Wittliff, Eugene R. Do Sombre, Elwood V. Jensen, Amnuay Singhakowinta, Samuel C. Brooks, James P. Neifeld

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Estrogen receptors (ER) were present in tumor specimens from 29 of 34 cases of male breast cancer. There was a significant negative correlation of ER concentration with age. The quantity of ER tended to correlate directly with progesterone receptor levels, disease-free interval, and response duration among responders, but not to a statistically significant extent. In 13 patients for whom response data were available, no significant correlation was observed between ER levels and either frequency or duration of orchiectomy response. Among the 6 patients with tumor ER levels of less than 30 fmol per mg of protein, however, only 2 brief responses to orchiectomy occurred that were of little clinical benefit, while 3 of 7 patients with higher ER responded more favorably. Thus, although this suggests that a relationship between low ER and unfavorable orchiectomy response may emerge as more patients are studied, currently available data do not justify basing therapeutic intervention on ER status of a biopsy in a manner analogous to that used for female breast cancer. Nine of 14 male breast cancer patients had positive progesterone receptor assays and several had androgen or glucocorticoid receptors. Tissue from only 3 of 10 men with gynecomastia had measurable ER, and these were limited to the 4S component on sucrose gradients.

Original languageEnglish (US)
Pages (from-to)991-997
Number of pages7
JournalCancer Research
Issue number4
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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