Clinical comparison of natural LH-RH, synthetic LH-RH, and two analogues of LH-RH

Abba J. Kastin; Andrew V. Schally; David Gonzalez-Barcena; David H. Coy; M. Clinton Miller; Hans Porias; Don S. Schalch

doi:10.1210/jcem-38-5-801

Clinical comparison of natural LH-RH, synthetic LH-RH, and two analogues of LH-RH

Abba J. Kastin, Andrew V. Schally, David Gonzalez-Barcena, David H. Coy, M. Clinton Miller, Hans Porias, Don S. Schalch

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two analogues of LH RH as well as pure, natural LH RH were compared with synthetic LH RH in normal men. The 9 ethylamide LH RH caused increments in plasma levels of LH and FSH comparable to those caused by synthetic LH RH given at double the dose level. About twice the amount of the 5 phenylalanine analogue, as compared with synthetic LH RH was required to release similar amounts of LH and FSH. Prolongation of action was found in some subjects by the addition of 16% gelatin to the im injections and mean maximum peaks may have been delayed when the 9 ethylamide LH RH was given as a rapid iv injection. Pure natural LH RH was as potent as the synthetic decapeptide.

Original language	English (US)
Pages (from-to)	801-804
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	38
Issue number	5
DOIs	https://doi.org/10.1210/jcem-38-5-801
State	Published - Jan 1 1974
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-38-5-801

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Clinical comparison of natural LH-RH, synthetic LH-RH, and two analogues of LH-RH. / Kastin, Abba J.; Schally, Andrew V.; Gonzalez-Barcena, David; Coy, David H.; Miller, M. Clinton; Porias, Hans; Schalch, Don S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 38, No. 5, 01.01.1974, p. 801-804.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two analogues of LH RH as well as pure, natural LH RH were compared with synthetic LH RH in normal men. The 9 ethylamide LH RH caused increments in plasma levels of LH and FSH comparable to those caused by synthetic LH RH given at double the dose level. About twice the amount of the 5 phenylalanine analogue, as compared with synthetic LH RH was required to release similar amounts of LH and FSH. Prolongation of action was found in some subjects by the addition of 16% gelatin to the im injections and mean maximum peaks may have been delayed when the 9 ethylamide LH RH was given as a rapid iv injection. Pure natural LH RH was as potent as the synthetic decapeptide.",

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AB - Two analogues of LH RH as well as pure, natural LH RH were compared with synthetic LH RH in normal men. The 9 ethylamide LH RH caused increments in plasma levels of LH and FSH comparable to those caused by synthetic LH RH given at double the dose level. About twice the amount of the 5 phenylalanine analogue, as compared with synthetic LH RH was required to release similar amounts of LH and FSH. Prolongation of action was found in some subjects by the addition of 16% gelatin to the im injections and mean maximum peaks may have been delayed when the 9 ethylamide LH RH was given as a rapid iv injection. Pure natural LH RH was as potent as the synthetic decapeptide.

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Clinical comparison of natural LH-RH, synthetic LH-RH, and two analogues of LH-RH

Abstract

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