Clinical comparison of natural LH-RH, synthetic LH-RH, and two analogues of LH-RH

Abba J. Kastin, Andrew V. Schally, David Gonzalez-Barcena, David H. Coy, M. Clinton Miller, Hans Porias, Don S. Schalch

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Two analogues of LH RH as well as pure, natural LH RH were compared with synthetic LH RH in normal men. The 9 ethylamide LH RH caused increments in plasma levels of LH and FSH comparable to those caused by synthetic LH RH given at double the dose level. About twice the amount of the 5 phenylalanine analogue, as compared with synthetic LH RH was required to release similar amounts of LH and FSH. Prolongation of action was found in some subjects by the addition of 16% gelatin to the im injections and mean maximum peaks may have been delayed when the 9 ethylamide LH RH was given as a rapid iv injection. Pure natural LH RH was as potent as the synthetic decapeptide.

Original languageEnglish (US)
Pages (from-to)801-804
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number5
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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