Clinical causes and treatment of the thrombotic storm

Thomas L. Ortel, Craig S. Kitchens, Doruk Erkan, Leonardo R. Brandão, Susan Estabrooks Hahn, Andra H. James, Roshni Kulkarni, Marilyn J. Manco-Johnson, Margaret Pericak-Vance, Jeffery Vance

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Thrombotic storm represents an extreme prothrombotic phenotype, characterized by multiple thrombotic events affecting diverse vascular beds occurring over a brief period of time. Thrombotic events involve venous and arterial circulation, including unusual locations, such as cerebral sinus venous thrombosis, intra-abdominal thromboembolic occlusions and microvascular events. Some patients will have antiphospholipid antibodies, but a significant number have no identifiable hypercoagulable state. The mainstay of treatment consists of anticoagulant therapy, although some patients appear to benefit from the addition of immunomodulatory therapies. Other disorders that share this thrombotic storm phenotype include catastrophic antiphospholipid syndrome, spontaneous heparin-induced thrombocytopenia and similar aggressive clinical disorders. Ongoing studies are focused on identifying underlying genetic factors that may predispose patients to develop this extreme clinical phenotype.

Original languageEnglish (US)
Pages (from-to)653-659
Number of pages7
JournalExpert Review of Hematology
Issue number6
StatePublished - Dec 2012


  • Anticoagulation
  • Catastrophic antiphospholipid syndrome
  • Genetics
  • Inherited thrombophilia
  • Thromboembolism
  • Thrombotic storm

ASJC Scopus subject areas

  • Hematology


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