Clinical-based cell therapies for heart disease-current and future state

Darren Turner, Angela C. Rieger, Wayne Balkan, Joshua M. Hare

Research output: Contribution to journalReview article

Abstract

Patients have an ongoing unmet need for effective therapies that reverse the cellular and functional damage associated with heart damage and disease. The discovery that ∼1%-2% of adult cardiomyocytes turn over per year provided the impetus for treatments that stimulate endogenous repair mechanisms that augment this rate. Preclinical and clinical studies provide evidence that cell-based therapy meets these therapeutic criteria. Recent and ongoing studies are focused on determining which cell type(s) works best for specific patient population(s) and the mechanism(s) by which these cells promote repair. Here we review clinical and preclinical stem cell studies and anticipate future directions of regenerative medicine for heart disease.

Original languageEnglish (US)
Article numbere0015
JournalRambam Maimonides Medical Journal
Volume11
Issue number2
DOIs
StatePublished - Apr 2020

Keywords

  • Cell therapy
  • Ischemic cardiomyopathy
  • Non-ischemic cardiomyopathy
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)

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